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Cereblon (CRBN)

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MRT2A; Mental Retardation,Non-Syndromic,Autosomal Recessive 2A

Cereblon (CRBN)
CCC G676
HGNC 30185
MGI 1913277
PubMed 22552008
RGD 1310533
UniProt Q96SW2
Wiki Cereblon
Cereblon is found on the human chromosome 3, on the short arm at position p26.3 from base pair 3,190,676 to base pair 3,221,394. CRBN orthologs are highly conserved from plants to humans.
Cereblon forms an E3 ubiquitin ligase complex with damaged DNA binding protein 1 (DDB1), Cullin-4A (CUL4A), and regulator of cullins 1 (ROC1). This complex ubiquitinates a number of other proteins. Through a mechanism which has not been completely elucidated, this ubiquitination results in increased levels of fibroblast growth factor 8 (FGF8). FGF8 in turn regulates a number of developmental processes, such as limb and auditory vesicle formation. The net result is that this ubiquitin ligase complex is important for limb outgrowth in embryos.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG676Hu01 Recombinant Cereblon (CRBN) Positive Control; Immunogen; SDS-PAGE; WB.
RPG676Hu02 Recombinant Cereblon (CRBN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG676Hu21 Monoclonal Antibody to Cereblon (CRBN) WB; IHC; ICC; IP.
PAG676Hu01 Polyclonal Antibody to Cereblon (CRBN) WB; IHC; ICC; IP.
Assay Kits SEG676Hu ELISA Kit for Cereblon (CRBN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG676Mu01 Recombinant Cereblon (CRBN) Positive Control; Immunogen; SDS-PAGE; WB.
RPG676Mu02 Recombinant Cereblon (CRBN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG676Mu01 Polyclonal Antibody to Cereblon (CRBN) WB; IHC; ICC; IP.
PAG676Mu02 Polyclonal Antibody to Cereblon (CRBN) WB; IHC; ICC; IP.
Assay Kits SEG676Mu ELISA Kit for Cereblon (CRBN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cereblon (CRBN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cereblon (CRBN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cereblon (CRBN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cereblon (CRBN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cereblon (CRBN) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "A mutation in a novel ATP-dependent Lon protease gene in a kindred with mild mental retardation."Neurology 63:1927-1931(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Primary function analysis of human mental retardation related gene CRBN."Mol. Biol. Rep. 35:251-256(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Dysregulation of large-conductance Ca2+-activated K+ channel expression in nonsyndromal mental retardation due to a cereblon p.R419X mutation."Neurogenetics 9:219-223(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of a primary target of thalidomide teratogenicity."Science 327:1345-1350(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.)."Br. J. Haematol. 164:811-821(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide." Nature 512:49-53(2014) [PubMed] [Europe PMC] [Abstract]
  12. "Structure of the human cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs."Nat. Struct. Mol. Biol. 21:803-809(2014) [PubMed] [Europe PMC] [Abstract]