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Mitotic Centromere Associated Kinesin (MCAK)

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KIF2C; KNSL6; Kinesin Family Member 2C; Kinesin-Like 6

Mitotic Centromere Associated Kinesin (MCAK)
CCC G678
HGNC 6393
MGI 1921054
RGD 620239
UniProt Q99661
KNSL6 shares 79.2% amino acid sequence homology with hamster Mcak, 63.2% homology with Xenopus XKCM1, 50.4% homology with mouse Kif2, and 33.7% homology with Xenopus DSK1.
Northern blot analysis detected an approximately 2.7- to 2.9-kb KNSL6 transcript at high levels in thymus and testis, at low levels in small intestine, the mucosal lining of colon, and placenta, and at very low levels in spleen and ovary; KNSL6 expression was not detected in prostate, peripheral blood leukocytes, heart, brain, lung, liver, skeletal muscle, kidney, or pancreas. The authors concluded that KNSL6 is expressed in tissues containing dividing cells. KNSL6 was not expressed in unstimulated T lymphocytes but was expressed in activated T cells during the S phase of the cell cycle.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins EPG678Hu61 Eukaryotic Mitotic Centromere Associated Kinesin (MCAK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Mitotic Centromere Associated Kinesin (MCAK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitotic Centromere Associated Kinesin (MCAK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitotic Centromere Associated Kinesin (MCAK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitotic Centromere Associated Kinesin (MCAK) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitotic Centromere Associated Kinesin (MCAK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitotic Centromere Associated Kinesin (MCAK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitotic Centromere Associated Kinesin (MCAK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitotic Centromere Associated Kinesin (MCAK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitotic Centromere Associated Kinesin (MCAK) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitotic Centromere Associated Kinesin (MCAK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitotic Centromere Associated Kinesin (MCAK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitotic Centromere Associated Kinesin (MCAK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitotic Centromere Associated Kinesin (MCAK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitotic Centromere Associated Kinesin (MCAK) ELISA Kit Customized Service Offer
  1. "Cloning and expression of human mitotic centromere-associated kinesin gene."Biochim. Biophys. Acta 1359:181-186(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Expression of a novel HsMCAK mRNA splice variant, tsMCAK gene, in human testis."Life Sci. 71:2741-2757(2002) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Human CENP-H multimers colocalize with CENP-A and CENP-C at active centromere-kinetochore complexes."Hum. Mol. Genet. 9:2919-2926(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Aurora B regulates MCAK at the mitotic centromere."Dev. Cell 6:253-268(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments."J. Cell Biol. 177:413-424(2007) [PubMed] [Europe PMC] [Abstract]
  8. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "An EB1-binding motif acts as a microtubule tip localization signal."Cell 138:366-376(2009) [PubMed] [Europe PMC] [Abstract]
  11. "TIP150 interacts with and targets MCAK at the microtubule plus ends."EMBO Rep. 10:857-865(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Genome stability is ensured by temporal control of kinetochore-microtubule dynamics."Nat. Cell Biol. 11:27-35(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Development and validation of a method for profiling post-translational modification activities using protein microarrays."PLoS ONE 5:E11332-E11332(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases."Curr. Biol. 21:1356-1365(2011) [PubMed] [Europe PMC] [Abstract]
  18. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  19. "Crystal structure of the KIF2C motor domain."Submitted (FEB-2009) to the PDB data bank