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Myopalladin (MYPN)

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MYOP; Sarcomeric Protein Myopalladin,145 kDa

Myopalladin (MYPN)
CCC G685
HGNC 23246
MGI 1916052
PubMed 11309420
RGD 1308510
UniProt Q86TC9
MYPN is a component of the sarcomere that tethers nebulin in skeletal muscle and nebulette in cardiac muscle to alpha-actinin at the Z lines.
The deduced 1,320-amino acid protein has a calculated molecular mass of 145 kD. It contains 5 immunoglobulin (Ig) repeats and 6 interdomain insertions. RNA dot blot analysis of multiple human tissues detected expression restricted to adult skeletal muscle and adult and fetal heart; fetal skeletal muscle was not examined. Immunofluorescent staining revealed that rat Mypn localized at the Z line of both heart and skeletal myofibrils, and it colocalized with cardiac ankyrin repeat protein (Carp) within the I band. Mypn localized to the nucleus in about 75% of isolated rat cardiac myocytes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG685Hu01 Recombinant Myopalladin (MYPN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG685Hu01 Polyclonal Antibody to Myopalladin (MYPN) WB; IHC; ICC; IP.
MAG685Hu21 Monoclonal Antibody to Myopalladin (MYPN) WB; IHC; ICC; IP.
Assay Kits SEG685Hu ELISA Kit for Myopalladin (MYPN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myopalladin (MYPN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myopalladin (MYPN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myopalladin (MYPN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myopalladin (MYPN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myopalladin (MYPN) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myopalladin (MYPN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myopalladin (MYPN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myopalladin (MYPN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myopalladin (MYPN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myopalladin (MYPN) ELISA Kit Customized Service Offer
  1. "Myopalladin, a novel 145-kilodalton sarcomeric protein with multiple roles in Z-disc and I-band protein assemblies."J. Cell Biol. 153:413-427(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Interaction of nebulin SH3 domain with titin PEVK and myopalladin: implications for the signaling and assembly role of titin and nebulin."FEBS Lett. 532:273-278(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Molecular basis for clinical heterogeneity in inherited cardiomyopathies due to myopalladin mutations." Hum. Mol. Genet. 21:2039-2053(2012) [PubMed] [Europe PMC] [Abstract]
  11. "Mutations in the Z-band protein myopalladin gene and idiopathic dilated cardiomyopathy."Cardiovasc. Res. 77:118-125(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Novel mutations in the sarcomeric protein myopalladin in patients with dilated cardiomyopathy."Eur. J. Hum. Genet. 21:294-300(2013) [PubMed] [Europe PMC] [Abstract]