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Tropomodulin 1 (TMOD1)

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ETMOD; TMOD; Erythrocyte tropomodulin

Tropomodulin 1 (TMOD1)
CCC G689
HGNC 11871
MGI 98775
PubMed 23144950
RGD 3874
UniProt P28289
Wiki TMOD1
TMOD1 encodes a member of the tropomodulin family. The encoded protein is an actin-capping protein that regulates tropomyosin by binding to its N-terminus, inhibiting depolymerization and elongation of the pointed end of actin filaments and thereby influencing the structure of the erythrocyte membrane skeleton.
TMOD gene is expressed in major human tissues at different levels in the following order: heart and skeletal muscle much greater than in brain, lung, and pancreas, which is greater than in placenta, liver, and kidney. They pointed to structural similarities between tropomodulin and the 64-kD autoantigen in Graves disease and suggested that the 2 genes evolved from a common ancestral gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG689Hu01 Recombinant Tropomodulin 1 (TMOD1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG689Hu01 Polyclonal Antibody to Tropomodulin 1 (TMOD1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Tropomodulin 1 (TMOD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tropomodulin 1 (TMOD1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tropomodulin 1 (TMOD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tropomodulin 1 (TMOD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tropomodulin 1 (TMOD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tropomodulin 1 (TMOD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tropomodulin 1 (TMOD1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tropomodulin 1 (TMOD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tropomodulin 1 (TMOD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tropomodulin 1 (TMOD1) Polyclonal Antibody Customized Service Offer
Assay Kits SEG689Ra ELISA Kit for Tropomodulin 1 (TMOD1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Molecular cloning and characterization of human fetal liver tropomodulin. A tropomyosin-binding protein."J. Biol. Chem. 267:2616-2621(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic organization of mouse and human erythrocyte tropomodulin genes encoding the pointed end capping protein for the actin filaments."Gene 256:271-281(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Erythrocyte tropomodulin binds to the N-terminus of hTM5, a tropomyosin isoform encoded by the gamma-tropomyosin gene."Biochem. Biophys. Res. Commun. 201:627-634(1994) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy." J. Clin. Invest. 124:4693-4708(2014) [PubMed] [Europe PMC] [Abstract]