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Obscurin (OBSCN)

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UNC89; ARHGEF30; Obscurin-MLCK; Cytoskeletal Calmodulin And Titin-Interacting RhoGEF; Obscurin-myosin light chain kinase

Obscurin (OBSCN)
CCC G690
HGNC 15719
MGI 2681862
PubMed 22573887
RGD 631335
UniProt Q5VST9
Wiki OBSCN
The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains.
This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. While several transcript variants likely exist for this gene, the full-length nature of only one has been described to date.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Obscurin (OBSCN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Obscurin (OBSCN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Obscurin (OBSCN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Obscurin (OBSCN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Obscurin (OBSCN) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Obscurin (OBSCN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Obscurin (OBSCN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Obscurin (OBSCN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Obscurin (OBSCN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Obscurin (OBSCN) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Obscurin (OBSCN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Obscurin (OBSCN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Obscurin (OBSCN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Obscurin (OBSCN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Obscurin (OBSCN) ELISA Kit Customized Service Offer
  1. "Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly."J. Cell Biol. 154:123-136(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "Complete human gene structure of obscurin: implications for isoform generation by differential splicing."J. Muscle Res. Cell Motil. 26:427-434(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
  5. "The complete gene sequence of titin, expression of an unusual ~700 kDa titin isoform and its interaction with obscurin identify a novel Z-line to I-band linking system."Circ. Res. 89:1065-1072(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Identification, tissue expression and chromosomal localization of human obscurin-MLCK, a member of the titin and Dbl families of myosin light chain kinases."Gene 282:237-246(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Binding of an ankyrin-1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated muscles."J. Cell Biol. 160:245-253(2003) [PubMed] [Europe PMC] [Abstract]
  8. "The parathyroid hormone-responsive B1 gene is interrupted by a t(1;7)(q42;p15) breakpoint associated with Wilms' tumour."Oncogene 22:1371-1380(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Essential role of obscurin in cardiac myofibrillogenesis and hypertrophic response: evidence from small interfering RNA-mediated gene silencing."Histochem. Cell Biol. 125:227-238(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Solution structure of the Ig domains of human obscurin."Submitted (AUG-2007) to the PDB data bank
  11. "Solution structure of the SH3 domain of obscurin."Submitted (APR-2005) to the PDB data bank
  12. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]