GA Binding Protein Transcription Factor Alpha (GABPa)

GABPa encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function.

This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype.The GABPA protein is closely related to the rat GA-binding protein alpha subunit, and the 53- and 47-kD proteins are related to the rat GABP beta subunits.