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G Protein Coupled Receptor 39 (GPR39)

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G Protein Coupled Receptor 39 (GPR39)
CCC G719
HGNC 4496
MGI 1918361
PubMed 16959833
UniProt O43194
Wiki GPR39
The growth hormone secretagogue receptor (GHSR) is a G protein-coupled receptor (GPCR) found in the pituitary gland and brain that is involved in the control of growth hormone release.
The predicted 453-amino acid GPR39 protein contains the 7 transmembrane domains characteristic of GPCRs. By sequence comparison with other GPCRs, McKee et al. (1997) found that the protein sequence of GPR39 is 27% and 32% identical to that of GSHR and neurotensin receptor-1, respectively. Northern blot analysis revealed that GPR39 is expressed widely as a 1.8- to 2-kb mRNA. A 3-kb transcript is present on Northern blots of some tissues, either in addition to the smaller mRNA or as the only hybridizing band.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG719Hu01 Recombinant G Protein Coupled Receptor 39 (GPR39) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to G Protein Coupled Receptor 39 (GPR39) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G Protein Coupled Receptor 39 (GPR39) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G Protein Coupled Receptor 39 (GPR39) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Protein Coupled Receptor 39 (GPR39) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G Protein Coupled Receptor 39 (GPR39) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G Protein Coupled Receptor 39 (GPR39) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G Protein Coupled Receptor 39 (GPR39) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G Protein Coupled Receptor 39 (GPR39) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Protein Coupled Receptor 39 (GPR39) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors."Genomics 46:426-434(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A second disulfide bridge from the N-terminal domain to extracellular loop 2 dampens receptor activity in GPR39."Biochemistry 47:9198-9207(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39."FEBS Lett. 582:2583-2588(2008) [PubMed] [Europe PMC] [Abstract]
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]