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G Protein Coupled Receptor 98 (GPR98)

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USH2B; FEB4; MASS1; USH2C; VLGR1; VLGR1b; Monogenic audiogenic seizure susceptibility protein 1; Usher syndrome type-2C protein; Very large G-protein coupled receptor 1

G Protein Coupled Receptor 98 (GPR98)
CCC G740
HGNC 17416
MGI 1274784
PubMed 22419726
UniProt Q8WXG9
Wiki GPR98
GPR98 encodes a member of the G-protein coupled receptor superfamily. The protein binds calcium and is expressed in the central nervous system. It is also known as very large G-protein coupled receptor 1 because it is 6300 residues long. It contains a C-terminal 7-transmembrane receptor domain, whereas the large N-terminal segment (5900 residues) includes 35 calcium binding Calx-beta domains, and 6 EAR domains.
Sequence analysis predicted that the 1,967-amino acid VLGR1 protein contains an N-terminal signal peptide, 7 putative Na(+)/Ca(2+) exchangers, 21 N-linked glycosylation sites, the TM region, and a C-terminal domain with a palmitoylation site and multiple potential serine phosphorylation sites.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G Protein Coupled Receptor 98 (GPR98) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G Protein Coupled Receptor 98 (GPR98) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G Protein Coupled Receptor 98 (GPR98) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G Protein Coupled Receptor 98 (GPR98) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Protein Coupled Receptor 98 (GPR98) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G Protein Coupled Receptor 98 (GPR98) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G Protein Coupled Receptor 98 (GPR98) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G Protein Coupled Receptor 98 (GPR98) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G Protein Coupled Receptor 98 (GPR98) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Protein Coupled Receptor 98 (GPR98) ELISA Kit Customized Service Offer
  1. "Sequence similarities between a novel putative G protein-coupled receptor and Na+/Ca2+ exchangers define a cation binding domain."Mol. Endocrinol. 14:1351-1364(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Very large G protein-coupled receptor-1, the largest known cell surface protein, is highly expressed in the developing central nervous system."J. Biol. Chem. 277:785-792(2002) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  8. "The DFNB31 gene product whirlin connects to the Usher protein network in the cochlea and retina by direct association with USH2A and VLGR1."Hum. Mol. Genet. 15:751-765(2006) [PubMed] [Europe PMC] [Abstract]
  9. "A nonsense mutation of the MASS1 gene in a family with febrile and afebrile seizures."Ann. Neurol. 52:654-657(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Mutations in the VLGR1 gene implicate G-protein signaling in the pathogenesis of Usher syndrome type II."Am. J. Hum. Genet. 74:357-366(2004) [PubMed] [Europe PMC] [Abstract]
  11. "PDZD7 is a modifier of retinal disease and a contributor to digenic Usher syndrome."J. Clin. Invest. 120:1812-1823(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Non-USH2A mutations in USH2 patients."Hum. Mutat. 33:504-510(2012) [PubMed] [Europe PMC] [Abstract]