≡

G Protein Coupled Receptor 81 (GPR81)

[Edit]

HCAR1; HCA1; FKSG80; GPR104; TA-GPCR; LACR1; Lactate Receptor 1; Hydroxycarboxylic acid receptor 1

G Protein Coupled Receptor 81 (GPR81)
CCC G741
HGNC 4532
MGI 2441671
PubMed 21751047
RGD 1586364
UniProt Q9BXC0
Wiki GPR81
G protein-coupled receptors (GPCRs, or GPRs), such as GPR81, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.
PCR primers were designed to amplify and clone GPR81 from a genomic library. Full-length GPR81 encodes a deduced 347-amino acid protein that shares 70%, 43%, and 37% sequence identity in the transmembrane regions with the chemokine receptor HM74, GPR31 , and the purinoceptor P2Y1, respectively. Northern blot analysis revealed a 1.0-kb transcript in human pituitary tissue, but not in any other brain region examined.GPR81 expression in adipose tissue. Little to no expression was detected in all other tissues examined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG741Hu01 Recombinant G Protein Coupled Receptor 81 (GPR81) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to G Protein Coupled Receptor 81 (GPR81) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G Protein Coupled Receptor 81 (GPR81) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G Protein Coupled Receptor 81 (GPR81) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Protein Coupled Receptor 81 (GPR81) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G Protein Coupled Receptor 81 (GPR81) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G Protein Coupled Receptor 81 (GPR81) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G Protein Coupled Receptor 81 (GPR81) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G Protein Coupled Receptor 81 (GPR81) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Protein Coupled Receptor 81 (GPR81) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G Protein Coupled Receptor 81 (GPR81) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G Protein Coupled Receptor 81 (GPR81) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G Protein Coupled Receptor 81 (GPR81) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G Protein Coupled Receptor 81 (GPR81) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Protein Coupled Receptor 81 (GPR81) ELISA Kit Customized Service Offer
  1. "Discovery and mapping of ten novel G protein-coupled receptor genes."Gene 275:83-91(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81."J. Biol. Chem. 284:2811-2822(2009) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of G protein-coupled receptor genes from the human genome sequence."FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
  5. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "International union of basic and clinical pharmacology. LXXXII: nomenclature and classification of hydroxy-carboxylic acid receptors (GPR81, GPR109A, and GPR109B)."Pharmacol. Rev. 63:269-290(2011) [PubMed] [Europe PMC] [Abstract]