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TNF Receptor Associated Factor 2 (TRAF2)

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TRAP; TRAP3; E3 ubiquitin-protein ligase TRAF2; Tumor necrosis factor type 2 receptor-associated protein 3

TNF Receptor Associated Factor 2 (TRAF2)
CCC G752
HGNC 12032
MGI 101835
PubMed 18981220
RGD 1310457
UniProt Q12933
Wiki TRAF2
TRAF2 directly interacts with TNF receptors, and forms complexes with other TRAF proteins. TRAF2 is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by TRAF2 and TRAF1 interacts with the IAP family members cIAP1 and cIAP2, and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. cIAP1 can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TNF Receptor Associated Factor 2 (TRAF2) Recombinant Protein Customized Service Offer
Antibodies PAG752Hu01 Polyclonal Antibody to TNF Receptor Associated Factor 2 (TRAF2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for TNF Receptor Associated Factor 2 (TRAF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for TNF Receptor Associated Factor 2 (TRAF2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG752Mu01 Recombinant TNF Receptor Associated Factor 2 (TRAF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG752Mu01 Polyclonal Antibody to TNF Receptor Associated Factor 2 (TRAF2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for TNF Receptor Associated Factor 2 (TRAF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for TNF Receptor Associated Factor 2 (TRAF2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TNF Receptor Associated Factor 2 (TRAF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TNF Receptor Associated Factor 2 (TRAF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TNF Receptor Associated Factor 2 (TRAF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TNF Receptor Associated Factor 2 (TRAF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for TNF Receptor Associated Factor 2 (TRAF2) ELISA Kit Customized Service Offer
  1. "Association of a RING finger protein with the cytoplasmic domain of the human type-2 tumour necrosis factor receptor."Biochem. J. 309:825-829(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor."Cell 78:681-692(1994) [PubMed] [Europe PMC] [Abstract]
  7. "T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor necrosis factor receptor-associated factors."J. Exp. Med. 183:669-674(1996) [PubMed] [Europe PMC] [Abstract]
  8. "I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction."Proc. Natl. Acad. Sci. U.S.A. 93:8241-8246(1996) [PubMed] [Europe PMC] [Abstract]
  9. "ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5."J. Biol. Chem. 272:13471-13474(1997) [PubMed] [Europe PMC] [Abstract]
  10. "TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation."J. Exp. Med. 185:1275-1285(1997) [PubMed] [Europe PMC] [Abstract]
  11. "MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1."Nature 385:540-544(1997) [PubMed] [Europe PMC] [Abstract]
  12. "CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization."Biochemistry 37:11836-11845(1998) [PubMed] [Europe PMC] [Abstract]
  13. "Identification of CARDIAK, a RIP-like kinase that associates with caspase-1."Curr. Biol. 8:885-888(1998) [PubMed] [Europe PMC] [Abstract]
  14. "The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2."Eur. J. Immunol. 28:2208-2216(1998) [PubMed] [Europe PMC] [Abstract]
  15. "Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation."J. Biol. Chem. 273:5808-5814(1998) [PubMed] [Europe PMC] [Abstract]
  16. "The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor."J. Biol. Chem. 273:28355-28359(1998) [PubMed] [Europe PMC] [Abstract]
  17. "Binding of CDK9 to TRAF2."J. Cell. Biochem. 71:467-478(1998) [PubMed] [Europe PMC] [Abstract]
  18. "CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand."J. Exp. Med. 187:1849-1862(1998) [PubMed] [Europe PMC] [Abstract]
  19. "ASK1 is essential for JNK/SAPK activation by TRAF2."Mol. Cell 2:389-395(1998) [PubMed] [Europe PMC] [Abstract]
  20. "4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB."Mol. Cell. Biol. 18:558-565(1998) [PubMed] [Europe PMC] [Abstract]
  21. "NF-kB activation by a signaling complex containing TRAF2, TANK, and TBK1, a novel IKK-related kinase."EMBO J. 18:6694-6704(1999) [PubMed] [Europe PMC] [Abstract]
  22. "Death deflected: IL-15 inhibits TNF-alpha-mediated apoptosis in fibroblasts by TRAF2 recruitment to the IL-15Ralpha chain."FASEB J. 13:1575-1585(1999) [PubMed] [Europe PMC] [Abstract]
  23. "Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain."Genes Dev. 13:1297-1308(1999) [PubMed] [Europe PMC] [Abstract]
  24. "Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand."J. Biol. Chem. 274:6056-6061(1999) [PubMed] [Europe PMC] [Abstract]
  25. "TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction."J. Biol. Chem. 274:30202-30208(1999) [PubMed] [Europe PMC] [Abstract]
  26. "TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton."J. Biol. Chem. 274:30729-30737(1999) [PubMed] [Europe PMC] [Abstract]
  27. "TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death."J. Biol. Chem. 275:15336-15342(2000) [PubMed] [Europe PMC] [Abstract]
  28. "TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation."J. Biol. Chem. 275:18586-18593(2000) [PubMed] [Europe PMC] [Abstract]
  29. "TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation." J. Exp. Med. 192:137-143(2000) [PubMed] [Europe PMC] [Abstract]
  30. "Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress."J. Biol. Chem. 276:13935-13940(2001) [PubMed] [Europe PMC] [Abstract]
  31. "Stress-induced decrease in TRAF2 stability is mediated by Siah2."EMBO J. 21:5756-5765(2002) [PubMed] [Europe PMC] [Abstract]
  32. "Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2."Mol. Cell. Biol. 22:737-749(2002) [PubMed] [Europe PMC] [Abstract]
  33. "TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2."Nature 416:345-347(2002) [PubMed] [Europe PMC] [Abstract]
  34. "CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members."Nature 424:793-796(2003) [PubMed] [Europe PMC] [Abstract]
  35. "The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination."Nature 424:801-805(2003) [PubMed] [Europe PMC] [Abstract]
  36. "AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation."J. Biol. Chem. 279:44955-44965(2004) [PubMed] [Europe PMC] [Abstract]
  37. "TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation."J. Biol. Chem. 279:55855-55865(2004) [PubMed] [Europe PMC] [Abstract]
  38. "TRAF family proteins link PKR with NF-kappa B activation."Mol. Cell. Biol. 24:4502-4512(2004) [PubMed] [Europe PMC] [Abstract]
  39. "VISA is an adapter protein required for virus-triggered IFN-beta Signaling."Mol. Cell 19:727-740(2005) [PubMed] [Europe PMC] [Abstract]
  40. "Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylation."Mol. Cell. Biol. 25:3886-3895(2005) [PubMed] [Europe PMC] [Abstract]
  41. "Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase."Nat. Immunol. 6:253-260(2005) [PubMed] [Europe PMC] [Abstract]
  42. "Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB."Cell. Signal. 18:83-92(2006) [PubMed] [Europe PMC] [Abstract]
  43. "RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation."J. Biol. Chem. 282:14788-14796(2007) [PubMed] [Europe PMC] [Abstract]
  44. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  45. "Enhanced cytoprotective effects of the inhibitor of apoptosis protein cellular IAP1 through stabilization with TRAF2."J. Biol. Chem. 284:20531-20539(2009) [PubMed] [Europe PMC] [Abstract]
  46. "PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination."Mol. Cell 33:30-42(2009) [PubMed] [Europe PMC] [Abstract]
  47. "TRAF2 phosphorylation modulates tumor necrosis factor alpha-induced gene expression and cell resistance to apoptosis."Mol. Cell. Biol. 29:303-314(2009) [PubMed] [Europe PMC] [Abstract]
  48. "TRAF2-MLK3 interaction is essential for TNF-alpha-induced MLK3 activation."Cell Res. 20:89-98(2010) [PubMed] [Europe PMC] [Abstract]
  49. "Asymmetric recruitment of cIAPs by TRAF2."J. Mol. Biol. 400:8-15(2010) [PubMed] [Europe PMC] [Abstract]
  50. "The RING domain of TRAF2 plays an essential role in the inhibition of TNFalpha-induced cell death but not in the activation of NF-kappaB."J. Mol. Biol. 396:528-539(2010) [PubMed] [Europe PMC] [Abstract]
  51. "Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation."Mol. Cell. Biochem. 338:11-17(2010) [PubMed] [Europe PMC] [Abstract]
  52. "Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway."Mol. Immunol. 47:1283-1291(2010) [PubMed] [Europe PMC] [Abstract]
  53. "Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2."Nature 465:1084-1088(2010) [PubMed] [Europe PMC] [Abstract]
  54. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  55. "Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes."Science 327:1135-1139(2010) [PubMed] [Europe PMC] [Abstract]
  56. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  57. "Alternative splicing of CARMA2/CARD14 transcripts generates protein variants with differential effect on NF-kappaB activation and endoplasmic reticulum stress-induced cell death."J. Cell. Physiol. 226:3121-3131(2011) [PubMed] [Europe PMC] [Abstract]
  58. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  59. "IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex."Cell Rep. 3:724-733(2013) [PubMed] [Europe PMC] [Abstract]
  60. "Structural basis for self-association and receptor recognition of human TRAF2."Nature 398:533-538(1999) [PubMed] [Europe PMC] [Abstract]
  61. "Crystallographic analysis of CD40 recognition and signaling by human TRAF2."Proc. Natl. Acad. Sci. U.S.A. 96:8408-8413(1999) [PubMed] [Europe PMC] [Abstract]
  62. "A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction."Cell 101:777-787(2000) [PubMed] [Europe PMC] [Abstract]
  63. "Structural basis for the lack of E2 interaction in the RING domain of TRAF2."Biochemistry 48:10558-10567(2009) [PubMed] [Europe PMC] [Abstract]
  64. "Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation."Mol. Cell 38:101-113(2010) [PubMed] [Europe PMC] [Abstract]