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TRAF Interacting Protein (TRAIP)

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TRIP; RNF206; Ring Finger Protein 206; E3 ubiquitin-protein ligase TRAIP

TRAF Interacting Protein (TRAIP)
CCC G756
HGNC 30764
MGI 1096377
PubMed 23291629
RGD 1309761
UniProt Q9BWF2
TRAIP encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis.
Sequence analysis predicted that the 469-amino acid human protein, which is 76% identical to the mouse protein, has an N-terminal RING finger motif and a putative coiled-coil domain. Northern blot analysis revealed highest expression of a 2.1-kb transcript in mouse testis, thymus, and spleen. Expression of Trip was reduced in activated lymphocytes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TRAF Interacting Protein (TRAIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TRAF Interacting Protein (TRAIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TRAF Interacting Protein (TRAIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TRAF Interacting Protein (TRAIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for TRAF Interacting Protein (TRAIP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TRAF Interacting Protein (TRAIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TRAF Interacting Protein (TRAIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TRAF Interacting Protein (TRAIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TRAF Interacting Protein (TRAIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for TRAF Interacting Protein (TRAIP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TRAF Interacting Protein (TRAIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TRAF Interacting Protein (TRAIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TRAF Interacting Protein (TRAIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TRAF Interacting Protein (TRAIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for TRAF Interacting Protein (TRAIP) ELISA Kit Customized Service Offer
  1. "TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation."J. Exp. Med. 185:1275-1285(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor."J. Exp. Med. 198:1959-1964(2003) [PubMed] [Europe PMC] [Abstract]
  5. "TRAF-interacting protein (TRIP) negatively regulates IFN-beta production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1."J. Exp. Med. 209:1703-1711(2012) [PubMed] [Europe PMC] [Abstract]
  6. "TRIP/NOPO E3 ubiquitin ligase promotes ubiquitylation of DNA polymerase eta."Development 141:1332-1341(2014) [PubMed] [Europe PMC] [Abstract]