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Lysosomal Trafficking Regulator (LYST)

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CHS1; Chediak-Higashi Syndrome 1; Beige homolog

Lysosomal Trafficking Regulator (LYST)
CCC G757
HGNC 1968
MGI 107448
PubMed 24521565
RGD 621837
UniProt Q99698
Wiki LYST
Lysosomal Trafficking Regulator regulates intracellular protein trafficking to and from the lysosome. Mutations in this gene are associated with Chediak-Higashi syndrome, a rare lysosomal storage disorder. Alternatively spliced transcript variants have been described but their full-length nature has not been determined.
The sequence of the 'beige' gene transcript showed strong nucleotide homology to multiple human ESTs, one or more of which may be associated with the gene that is mutant in Chediak-Higashi syndrome. The predicted 2,186-amino acid polypeptide shows significant amino acid homology to orphan proteins identified in Saccharomyces cerevisiae (CDC4), Caenorhabditis elegans, and humans (CDC4L).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lysosomal Trafficking Regulator (LYST) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lysosomal Trafficking Regulator (LYST) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lysosomal Trafficking Regulator (LYST) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lysosomal Trafficking Regulator (LYST) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lysosomal Trafficking Regulator (LYST) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lysosomal Trafficking Regulator (LYST) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lysosomal Trafficking Regulator (LYST) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lysosomal Trafficking Regulator (LYST) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lysosomal Trafficking Regulator (LYST) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lysosomal Trafficking Regulator (LYST) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lysosomal Trafficking Regulator (LYST) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lysosomal Trafficking Regulator (LYST) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lysosomal Trafficking Regulator (LYST) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lysosomal Trafficking Regulator (LYST) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lysosomal Trafficking Regulator (LYST) ELISA Kit Customized Service Offer
  1. "Identification and mutation analysis of the complete gene for Chediak-Higashi syndrome."Nat. Genet. 14:307-311(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of the homologous beige and Chediak-Higashi syndrome genes."Nature 382:262-265(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of mutations in two major mRNA isoforms of the Chediak-Higashi syndrome gene in human and mouse."Hum. Mol. Genet. 6:1091-1098(1997) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins."Mol. Med. 8:56-64(2002) [PubMed] [Europe PMC] [Abstract]
  6. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Apparent genotype-phenotype correlation in childhood, adolescent, and adult Chediak-Higashi syndrome."Am. J. Med. Genet. 108:16-22(2002) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Autosomal-recessive complicated spastic paraplegia with a novel lysosomal trafficking regulator gene mutation."J. Neurol. Neurosurg. Psych. 85:1024-1028(2014) [PubMed] [Europe PMC] [Abstract]