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Abnormal Spindle Like Microcephaly Associated Protein (ASPM)

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ASP; MCPH5; Calmbp1; Abnormal Spindle Protein Homolog; Asp Homolog ; Microcephaly,Primary Autosomal Recessive 5

Abnormal Spindle Like Microcephaly Associated Protein (ASPM)
CCC G765
HGNC 19048
MGI 1334448
PubMed 15972725
RGD 1307111
UniProt Q8IZT6
Wiki ASPM
ASPM is located on chromosome 1, band q31 (1q31). Defective forms of the ASPM gene are associated with autosomal recessive primary microcephaly.
"ASPM" is an acronym for "Abnormal Spindle-like, Microcephaly-associated", which reflects its being an ortholog to the Drosophila melanogaster "abnormal spindle" (asp) gene. The expressed protein product of the asp gene is essential for normal mitotic spindle function in embryonic neuroblasts.The mouse gene, Aspm, is expressed in the primary sites of prenatal cerebral cortical neurogenesis. The difference between Aspm and ASPM is a single, large insertion coding for so-called IQ domains. Studies in mice also suggest a role of the expressed Aspm gene product in mitotic spindle regulation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Abnormal Spindle Like Microcephaly Associated Protein (ASPM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Abnormal Spindle Like Microcephaly Associated Protein (ASPM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Abnormal Spindle Like Microcephaly Associated Protein (ASPM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Abnormal Spindle Like Microcephaly Associated Protein (ASPM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Abnormal Spindle Like Microcephaly Associated Protein (ASPM) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Abnormal Spindle Like Microcephaly Associated Protein (ASPM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Abnormal Spindle Like Microcephaly Associated Protein (ASPM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Abnormal Spindle Like Microcephaly Associated Protein (ASPM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Abnormal Spindle Like Microcephaly Associated Protein (ASPM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Abnormal Spindle Like Microcephaly Associated Protein (ASPM) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Abnormal Spindle Like Microcephaly Associated Protein (ASPM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Abnormal Spindle Like Microcephaly Associated Protein (ASPM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Abnormal Spindle Like Microcephaly Associated Protein (ASPM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Abnormal Spindle Like Microcephaly Associated Protein (ASPM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Abnormal Spindle Like Microcephaly Associated Protein (ASPM) ELISA Kit Customized Service Offer
  1. "ASPM is a major determinant of cerebral cortical size."Nat. Genet. 32:316-320(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Evolution of the human ASPM gene, a major determinant of brain size."Genetics 165:2063-2070(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The microcephaly ASPM gene is expressed in proliferating tissues and encodes for a mitotic spindle protein."Hum. Mol. Genet. 14:2155-2165(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Protein-truncating mutations in ASPM cause variable reduction in brain size."Am. J. Hum. Genet. 73:1170-1177(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Investigation of primary microcephaly in Bushehr province of Iran: novel STIL and ASPM mutations."Clin. Genet. 83:488-490(2013) [PubMed] [Europe PMC] [Abstract]
  14. "Genetic studies of autosomal recessive primary microcephaly in 33 Pakistani families: Novel sequence variants in ASPM gene."Neurogenetics 7:105-110(2006) [PubMed] [Europe PMC] [Abstract]
  15. "A common SNP of MCPH1 is associated with cranial volume variation in Chinese population."Hum. Mol. Genet. 17:1329-1335(2008) [PubMed] [Europe PMC] [Abstract]