≡

Crk Like Protein (CRKL)

[Edit]

V-Crk Sarcoma Virus CT10 Oncogene Homolog(avian)-Like

Crk Like Protein (CRKL)
CCC G766
HGNC 2363
MGI 104686
PubMed 24145029
RGD 1308531
UniProt P46109
Wiki CRKL
v-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains. CRKL has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase and plays a role in fibroblast transformation by BCR-ABL.
In addition, CRKL has oncogenic potential.CrkL together with Crk participates in the Reelin signaling cascade downstream of DAB1.CRKL becomes phosphorylated when overexpressed, activates Ras-dependent and JNK pathways, and transforms fibroblasts. The authors also found CRKL to be a substrate for the BCR-ABL tyrosine kinase (ABL), leading them to conclude that CRKL is a tyrosine kinase and an oncogene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG766Hu01 Recombinant Crk Like Protein (CRKL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG766Hu21 Monoclonal Antibody to Crk Like Protein (CRKL) WB; IHC; ICC; IP.
PAG766Hu01 Polyclonal Antibody to Crk Like Protein (CRKL) WB; IHC; ICC; IP.
Assay Kits SEG766Hu ELISA Kit for Crk Like Protein (CRKL) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG766Mu01 Recombinant Crk Like Protein (CRKL) Positive Control; Immunogen; SDS-PAGE; WB.
RPG766Mu02 Recombinant Crk Like Protein (CRKL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG766Mu01 Polyclonal Antibody to Crk Like Protein (CRKL) WB; IHC; ICC; IP.
PAG766Mu02 Polyclonal Antibody to Crk Like Protein (CRKL) WB; IHC; ICC; IP.
Assay Kits SEG766Mu ELISA Kit for Crk Like Protein (CRKL) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Crk Like Protein (CRKL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Crk Like Protein (CRKL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Crk Like Protein (CRKL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Crk Like Protein (CRKL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Crk Like Protein (CRKL) ELISA Kit Customized Service Offer
  1. "Isolation and chromosomal localization of CRKL, a human crk-like gene."Oncogene 8:2469-2474(1993) [PubMed] [Europe PMC] [Abstract]
  2. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction."J. Biol. Chem. 273:14780-14787(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation."Oncogene 18:1147-1156(1999) [PubMed] [Europe PMC] [Abstract]
  7. "DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines."Blood 100:3968-3974(2002) [PubMed] [Europe PMC] [Abstract]
  8. "CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling."J. Biol. Chem. 276:33282-33290(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Solution structures of the SH3 domain of human CRK-like protein."Submitted (DEC-2006) to the PDB data bank