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V-Crk Sarcoma Virus CT10 Oncogene Homolog (CRK)

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CRKII; p38; Proto-oncogene c-Crk

V-Crk Sarcoma Virus CT10 Oncogene Homolog (CRK)
CCC G767
HGNC 2362
MGI 88508
PubMed 1690891
RGD 2405
UniProt P46108
Wiki CRK
CRK is a gene which codes a protein exhibiting the SH2 domain.This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.Crk together with CrkL participates in the Reelin signaling cascade downstream of DAB1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant V-Crk Sarcoma Virus CT10 Oncogene Homolog (CRK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to V-Crk Sarcoma Virus CT10 Oncogene Homolog (CRK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to V-Crk Sarcoma Virus CT10 Oncogene Homolog (CRK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for V-Crk Sarcoma Virus CT10 Oncogene Homolog (CRK) CLIA Kit Customized Service Offer
n/a ELISA Kit for V-Crk Sarcoma Virus CT10 Oncogene Homolog (CRK) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant V-Crk Sarcoma Virus CT10 Oncogene Homolog (CRK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to V-Crk Sarcoma Virus CT10 Oncogene Homolog (CRK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to V-Crk Sarcoma Virus CT10 Oncogene Homolog (CRK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for V-Crk Sarcoma Virus CT10 Oncogene Homolog (CRK) CLIA Kit Customized Service Offer
n/a ELISA Kit for V-Crk Sarcoma Virus CT10 Oncogene Homolog (CRK) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant V-Crk Sarcoma Virus CT10 Oncogene Homolog (CRK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to V-Crk Sarcoma Virus CT10 Oncogene Homolog (CRK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to V-Crk Sarcoma Virus CT10 Oncogene Homolog (CRK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for V-Crk Sarcoma Virus CT10 Oncogene Homolog (CRK) CLIA Kit Customized Service Offer
n/a ELISA Kit for V-Crk Sarcoma Virus CT10 Oncogene Homolog (CRK) ELISA Kit Customized Service Offer
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  20. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  21. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Unc119 protects from Shigella infection by inhibiting the Abl family kinases."PLoS ONE 4:E5211-E5211(2009) [PubMed] [Europe PMC] [Abstract]
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  24. ErratumProc. Natl. Acad. Sci. U.S.A. 107:13556-13556(2010)
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  30. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
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