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N-Acetyltransferase 10 (NAT10)

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ALP; hALP; NET43; N-Acetyltransferase 10(GCN5-Related)

N-Acetyltransferase 10 (NAT10)
CCC G771
HGNC 29830
MGI 2138939
PubMed 19303003
UniProt Q9H0A0
Wiki NAT10
Cotransfection of HeLa cells with a reporter construct driven by the TERT promoter and ALP cDNA resulted in increased reporter activity. Cotransfection of the reporter with antisense ALP cDNA resulted decreased reporter activity. Cells overexpressing ALP showed higher telomerase activity, whereas cells with antisense ALP showed decreased telomerase activity. In vitro analysis showed that ALP specifically catalyzed acetylation of histones.
The deduced 834-amino acid protein has a calculated molecular mass of 94 kD. ALP contains an N-acetyltransferase domain accompanied by an ATP/GTP-binding motif and an ATPase domain. Western blot analysis of HeLa cells detected ALP at an apparent molecular mass of 94 kD. Immunocytochemical analysis detected ALP mainly in HeLa cell nuclei.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant N-Acetyltransferase 10 (NAT10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to N-Acetyltransferase 10 (NAT10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to N-Acetyltransferase 10 (NAT10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for N-Acetyltransferase 10 (NAT10) CLIA Kit Customized Service Offer
n/a ELISA Kit for N-Acetyltransferase 10 (NAT10) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant N-Acetyltransferase 10 (NAT10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to N-Acetyltransferase 10 (NAT10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to N-Acetyltransferase 10 (NAT10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for N-Acetyltransferase 10 (NAT10) CLIA Kit Customized Service Offer
n/a ELISA Kit for N-Acetyltransferase 10 (NAT10) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Molecular cloning of a novel human gene encoding histone acetyltransferase-like protein involved in transcriptional activation of hTERT."Biochem. Biophys. Res. Commun. 311:506-513(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Functional proteomic analysis of human nucleolus."Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Histone acetyltransferase hALP and nuclear membrane protein hsSUN1 function in de-condensation of mitotic chromosomes."J. Biol. Chem. 282:27447-27458(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation."Mol. Cell 28:773-785(2007) [PubMed] [Europe PMC] [Abstract]
  10. "DNA damage induces N-acetyltransferase NAT10 gene expression through transcriptional activation."Mol. Cell. Biochem. 300:249-258(2007) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "NAT10, a nucleolar protein, localizes to the midbody and regulates cytokinesis and acetylation of microtubules."Exp. Cell Res. 315:1653-1667(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]