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NK3 Homeobox Protein 1 (NKX3-1)

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BAPX2; NKX3; NKX3.1; NKX3A; NK3 transcription factor related, locus 1; Homeobox protein NK-3 homolog A

NK3 Homeobox Protein 1 (NKX3-1)
CCC G780
HGNC 7838
MGI 97352
PubMed 20588175
RGD 1305369
UniProt Q99801
Wiki NKX3-1
The homeodomain-containing transcription factor NKX3-1 is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. Loss of NKX3-1 protein expression is a common finding in human prostate carcinomas and prostatic intraepithelial neoplasia.
NKX3.1, encodes a deduced 234-amino acid polypeptide with greatest homology to the Drosophila NK3 gene. Northern blot analysis showed that NKX3.1 had a uniquely restricted tissue expression pattern. The 3.5-kb NKX3.1 mRNA was abundant in the prostate, present at a lower level in the testis, and absent from all other tissues tested. Androgen stimulation markedly increased NKX3.1 expression in an androgen-dependent carcinoma line.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NK3 Homeobox Protein 1 (NKX3-1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NK3 Homeobox Protein 1 (NKX3-1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NK3 Homeobox Protein 1 (NKX3-1) Polyclonal Antibody Customized Service Offer
Assay Kits SEG780Hu ELISA Kit for NK3 Homeobox Protein 1 (NKX3-1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NK3 Homeobox Protein 1 (NKX3-1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NK3 Homeobox Protein 1 (NKX3-1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NK3 Homeobox Protein 1 (NKX3-1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NK3 Homeobox Protein 1 (NKX3-1) CLIA Kit Customized Service Offer
n/a ELISA Kit for NK3 Homeobox Protein 1 (NKX3-1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NK3 Homeobox Protein 1 (NKX3-1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NK3 Homeobox Protein 1 (NKX3-1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NK3 Homeobox Protein 1 (NKX3-1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NK3 Homeobox Protein 1 (NKX3-1) CLIA Kit Customized Service Offer
n/a ELISA Kit for NK3 Homeobox Protein 1 (NKX3-1) ELISA Kit Customized Service Offer
  1. "A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deleted in prostate cancer."Genomics 43:69-77(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation and androgen regulation of the human homeobox cDNA, NKX3.1."Prostate 35:71-80(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Full-length cDNA sequence and genomic organization of human NKX3A --alternative mRNA forms and regulation by both androgens and estrogens."Gene 260:25-36(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter."Cancer Res. 62:338-340(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Purification and identification of a novel complex which is involved in androgen receptor-dependent transcription."Mol. Cell. Biol. 23:7019-7029(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Ubiquitination by TOPORS regulates the prostate tumor suppressor NKX3.1."J. Biol. Chem. 283:4834-4840(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Gene expression profiles in the PC-3 human prostate cancer cells induced by NKX3.1."Mol. Biol. Rep. 37:1505-1512(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Solution NMR structure of homeobox domain of homeobox protein NKX-3.1 from Homo sapiens, Northeast structural genomics consortium target HR6470A."Submitted (APR-2011) to the PDB data bank
  10. "Coding region of NKX3.1, a prostate-specific homeobox gene on 8p21, is not mutated in human prostate cancers."Cancer Res. 57:4455-4459(1997) [PubMed] [Europe PMC] [Abstract]
  11. ErratumCancer Res. 57:5613-5613(1997)