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Polo Like Kinase 4 (PLK4)

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SAK; STK18; Serine/Threonine Kinase 18; Serine/threonine-protein kinase PLK4

Polo Like Kinase 4 (PLK4)
CCC G784
HGNC 11397
MGI 101783
PubMed 23019411
RGD 1305390
UniProt O00444
Wiki PLK4
PLK4 encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle.
Chromosomal segregation during mitosis and meiosis is regulated by kinases and phosphatases. The predicted 970-amino acid STK18 protein shares significant homology with other STKs, particularly to those related to Drosophila 'polo', all of which have an N-terminal kinase domain. Because STK18 is homologous to the murine Sak gene, the authors designated it SAK. Northern blot analysis detected abundant expression of a 4.0-kb STK18 transcript in testis and thymus but not in other tissues or tumors.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Polo Like Kinase 4 (PLK4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Polo Like Kinase 4 (PLK4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Polo Like Kinase 4 (PLK4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Polo Like Kinase 4 (PLK4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Polo Like Kinase 4 (PLK4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Polo Like Kinase 4 (PLK4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Polo Like Kinase 4 (PLK4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Polo Like Kinase 4 (PLK4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Polo Like Kinase 4 (PLK4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Polo Like Kinase 4 (PLK4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Polo Like Kinase 4 (PLK4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Polo Like Kinase 4 (PLK4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Polo Like Kinase 4 (PLK4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Polo Like Kinase 4 (PLK4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Polo Like Kinase 4 (PLK4) ELISA Kit Customized Service Offer
  1. "Human SAK related to the PLK/polo family of cell cycle kinases shows high mRNA expression in testis."Oncol. Rep. 4:505-510(1997)
  2. "Sak serine-threonine kinase acts as an effector of Tec tyrosine kinase."J. Biol. Chem. 276:39012-39020(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Transmembrane signaling by the interleukin-2 receptor: progress and conundrums."Semin. Immunol. 5:345-364(1993) [PubMed] [Europe PMC] [Abstract]
  6. "Analysis of tyrosine kinase mRNAs including four FGF receptor mRNAs expressed in MCF-7 breast-cancer cells."Int. J. Cancer 50:598-603(1992) [PubMed] [Europe PMC] [Abstract]
  7. "SAK/PLK4 is required for centriole duplication and flagella development."Curr. Biol. 15:2199-2207(2005) [PubMed] [Europe PMC] [Abstract]
  8. "The Polo kinase Plk4 functions in centriole duplication."Nat. Cell Biol. 7:1140-1146(2005) [PubMed] [Europe PMC] [Abstract]
  9. "SAK, a new polo-like kinase, is transcriptionally repressed by p53 and induces apoptosis upon RNAi silencing."Neoplasia 7:312-323(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Plk4-induced centriole biogenesis in human cells."Dev. Cell 13:190-202(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Human Plk4 phosphorylates Cdc25C."Cell Cycle 7:545-547(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Polo-like kinase 4 phosphorylates Chk2."Cell Cycle 8:327-329(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Gamma-tubulin-containing abnormal centrioles are induced by insufficient Plk4 in human HCT116 colorectal cancer cells."J. Cell Sci. 122:2014-2023(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome."J. Cell Biol. 191:731-739(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Asterless is a scaffold for the onset of centriole assembly."Nature 467:714-718(2010) [PubMed] [Europe PMC] [Abstract]
  19. "The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication."Nat. Cell Biol. 13:1004-1009(2011) [PubMed] [Europe PMC] [Abstract]
  20. "Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy." Nat. Genet. 46:1283-1292(2014) [PubMed] [Europe PMC] [Abstract]
  21. "Crystal structure of PLK4 kinase."Submitted (JUN-2009) to the PDB data bank
  22. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]