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Translocation Associated Notch Homolog 1 (TAN1)

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NOTCH1; hN1; NEXT; NICD; Translocation-associated notch protein TAN-1

Translocation Associated Notch Homolog 1 (TAN1)
CCC G797
HGNC 7881
MGI 97363
RGD 3187
UniProt P46531
NOTCH1 encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types.
Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG797Hu01 Recombinant Translocation Associated Notch Homolog 1 (TAN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG797Hu01 Polyclonal Antibody to Translocation Associated Notch Homolog 1 (TAN1) WB; IHC; ICC; IP.
Assay Kits SEG797Hu ELISA Kit for Translocation Associated Notch Homolog 1 (TAN1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG797Mu01 Recombinant Translocation Associated Notch Homolog 1 (TAN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG797Mu01 Polyclonal Antibody to Translocation Associated Notch Homolog 1 (TAN1) WB; IHC; ICC; IP.
Assay Kits SEG797Mu ELISA Kit for Translocation Associated Notch Homolog 1 (TAN1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Translocation Associated Notch Homolog 1 (TAN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Translocation Associated Notch Homolog 1 (TAN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Translocation Associated Notch Homolog 1 (TAN1) Polyclonal Antibody Customized Service Offer
Assay Kits SEG797Ra ELISA Kit for Translocation Associated Notch Homolog 1 (TAN1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Translocation Associated Notch Homolog 1 (TAN1) Recombinant Protein Customized Service Offer
Antibodies PAG797Rb01 Polyclonal Antibody to Translocation Associated Notch Homolog 1 (TAN1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Translocation Associated Notch Homolog 1 (TAN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Translocation Associated Notch Homolog 1 (TAN1) ELISA Kit Customized Service Offer
  1. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  2. "TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms."Cell 66:649-661(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor."J. Biol. Chem. 282:24027-24038(2007) [PubMed] [Europe PMC] [Abstract]
  4. "Human ligands of the Notch receptor."Am. J. Pathol. 154:785-794(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Human deltex is a conserved regulator of Notch signalling."Nat. Genet. 19:74-78(1998) [PubMed] [Europe PMC] [Abstract]
  6. "SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function."Mol. Cell. Biol. 20:2400-2410(2000) [PubMed] [Europe PMC] [Abstract]
  7. "MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors."Nat. Genet. 26:484-489(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors."Mol. Cell. Biol. 22:7688-7700(2002) [PubMed] [Europe PMC] [Abstract]
  9. "AIP4/Itch regulates Notch receptor degradation in the absence of ligand."PLoS ONE 3:E2735-E2735(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis."Circ. Res. 107:592-601(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Notch1 binds and induces degradation of Snail in hepatocellular carcinoma."BMC Biol. 9:83-83(2011) [PubMed] [Europe PMC] [Abstract]
  13. "The adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathway."J. Biol. Chem. 286:18720-18730(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Serum- and glucocorticoid-inducible kinase 1 (SGK1) controls Notch1 signaling by downregulation of protein stability through Fbw7 ubiquitin ligase."J. Cell Sci. 124:100-112(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Assembly of a Notch transcriptional activation complex requires multimerization."Mol. Cell. Biol. 31:1396-1408(2011) [PubMed] [Europe PMC] [Abstract]
  16. "The heterotaxy gene GALNT11 glycosylates Notch to orchestrate cilia type and laterality."Nature 504:456-459(2013) [PubMed] [Europe PMC] [Abstract]
  17. "Identifying tandem Ankyrin repeats in protein structures."BMC Bioinformatics 15:6599-6599(2014) [PubMed] [Europe PMC] [Abstract]
  18. "Nuclear magnetic resonance structure of a prototype Lin12-Notch repeat module from human Notch1."Biochemistry 42:7061-7067(2003) [PubMed] [Europe PMC] [Abstract]
  19. "Structural and functional properties of the human notch-1 ligand binding region."Structure 12:2173-2183(2004) [PubMed] [Europe PMC] [Abstract]
  20. "High-resolution crystal structure of the human Notch 1 ankyrin domain."Biochem. J. 392:13-20(2005) [PubMed] [Europe PMC] [Abstract]
  21. "Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes."Cell 124:973-983(2006) [PubMed] [Europe PMC] [Abstract]
  22. "Mutations in NOTCH1 cause aortic valve disease."Nature 437:270-274(2005) [PubMed] [Europe PMC] [Abstract]
  23. "Mutations in NOTCH1 cause Adams-Oliver syndrome."Am. J. Hum. Genet. 95:275-284(2014) [PubMed] [Europe PMC] [Abstract]