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Lysine Specific Demethylase 3A (KDM3A)

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JMJD1; JMJD1A; TSGA; JHMD2A; JmjC domain-containing histone demethylation protein 2A; Jumonji domain-containing protein 1A

Lysine Specific Demethylase 3A (KDM3A)
CCC G805
HGNC 20815
MGI 98847
PubMed 24362521
RGD 708351
UniProt Q9Y4C1
The deduced protein contains 1,236 amino acids. RT-PCR ELISA detected highest expression in testis, followed by ovary, kidney, lung, heart, and brain. Moderate expression was detected in liver, skeletal muscle, pancreas, and spleen.
Mutation studies showed that the JmjC domain and zinc finger of JMJD1A were required for its enzymatic activity. Overexpression of JMJD1A in COS cells reduced H3K9 methylation, and knockdown of JMJD1A in mouse cells resulted in increased dimethyl-K9 levels at the promoter region of a subset of genes concomitant with their decreased expression. JMJD1A exhibited hormone-dependent recruitment to androgen receptor (AR) target genes in a human prostate cancer cell line, resulting in H3K9 demethylation and transcriptional activation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lysine Specific Demethylase 3A (KDM3A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lysine Specific Demethylase 3A (KDM3A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lysine Specific Demethylase 3A (KDM3A) Polyclonal Antibody Customized Service Offer
Assay Kits SEG805Hu ELISA Kit for Lysine Specific Demethylase 3A (KDM3A) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lysine Specific Demethylase 3A (KDM3A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lysine Specific Demethylase 3A (KDM3A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lysine Specific Demethylase 3A (KDM3A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lysine Specific Demethylase 3A (KDM3A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lysine Specific Demethylase 3A (KDM3A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lysine Specific Demethylase 3A (KDM3A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lysine Specific Demethylase 3A (KDM3A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lysine Specific Demethylase 3A (KDM3A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lysine Specific Demethylase 3A (KDM3A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lysine Specific Demethylase 3A (KDM3A) ELISA Kit Customized Service Offer
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  4. "JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor."Cell 125:483-495(2006) [PubMed] [Europe PMC] [Abstract]
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