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Lysine Specific Demethylase 5C (KDM5C)

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SMCX; JARID1C; XE169; Smcy Homolog,X-linked; Jumonji,AT Rich Interactive Domain 1C; Histone demethylase JARID1C

Lysine Specific Demethylase 5C (KDM5C)
CCC G813
HGNC 11114
MGI 99781
PubMed 22326837
UniProt P41229
KDM5C is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Alternative splicing generates 2 distinct transcripts, either containing or missing 9 nucleotides, which in turn predicts 2 XE169 protein isoforms composed of 1,557 and 1,560 amino acids, respectively. XE169 is expressed in multiple human tissues, and homologous sequences exist on the human Y chromosome and in the genomes of 5 other eutherian mammals examined. RT-PCR analysis of somatic cell hybrids containing either an active or an inactive human X chromosome on a rodent background demonstrated that XE169 escapes X inactivation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lysine Specific Demethylase 5C (KDM5C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lysine Specific Demethylase 5C (KDM5C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lysine Specific Demethylase 5C (KDM5C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lysine Specific Demethylase 5C (KDM5C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lysine Specific Demethylase 5C (KDM5C) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lysine Specific Demethylase 5C (KDM5C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lysine Specific Demethylase 5C (KDM5C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lysine Specific Demethylase 5C (KDM5C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lysine Specific Demethylase 5C (KDM5C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lysine Specific Demethylase 5C (KDM5C) ELISA Kit Customized Service Offer
  1. "Isolation and characterization of XE169, a novel human gene that escapes X-inactivation."Hum. Mol. Genet. 3:153-160(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A novel X gene with a widely transcribed Y-linked homologue escapes X-inactivation in mouse and human."Hum. Mol. Genet. 3:879-884(1994) [PubMed] [Europe PMC] [Abstract]
  6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  7. "RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3."Cell 128:1063-1076(2007) [PubMed] [Europe PMC] [Abstract]
  8. "The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases."Cell 128:1077-1088(2007) [PubMed] [Europe PMC] [Abstract]
  9. "The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation."Nature 447:601-605(2007) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Mutations in the JARID1C gene, which is involved in transcriptional regulation and chromatin remodeling, cause X-linked mental retardation."Am. J. Hum. Genet. 76:227-236(2005) [PubMed] [Europe PMC] [Abstract]
  16. "A novel mutation in JARID1C gene associated with mental retardation."Eur. J. Hum. Genet. 14:583-586(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Novel JARID1C/SMCX mutations in patients with X-linked mental retardation."Hum. Mutat. 27:389-389(2006) [PubMed] [Europe PMC] [Abstract]
  18. "A de novo paradigm for mental retardation."Nat. Genet. 42:1109-1112(2010) [PubMed] [Europe PMC] [Abstract]