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Polyamine Oxidase (PAOX)

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PAO; Peroxisomal N(1)-Acetyl-Spermine/Spermidine Oxidase(Exo-N4-Amino)

Polyamine Oxidase (PAOX)
CCC G817
HGNC 20837
MGI 1916983
PubMed 16600031
RGD 1561125
UniProt Q6QHF9
Wiki PAOX
Polyamine Oxidaseis an enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with oxygen as acceptor. Widely expressed. Not detected in spleen. Expressed at lower level in neoplastic tissues.
Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N1,N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG817Hu01 Recombinant Polyamine Oxidase (PAOX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Polyamine Oxidase (PAOX) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Polyamine Oxidase (PAOX) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Polyamine Oxidase (PAOX) CLIA Kit Customized Service Offer
n/a ELISA Kit for Polyamine Oxidase (PAOX) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG817Mu01 Recombinant Polyamine Oxidase (PAOX) Positive Control; Immunogen; SDS-PAGE; WB.
RPG817Mu02 Recombinant Polyamine Oxidase (PAOX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG817Mu01 Polyclonal Antibody to Polyamine Oxidase (PAOX) WB; IHC; ICC; IP.
PAG817Mu02 Polyclonal Antibody to Polyamine Oxidase (PAOX) WB; IHC; ICC; IP.
Assay Kits SEG817Mu ELISA Kit for Polyamine Oxidase (PAOX) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Polyamine Oxidase (PAOX) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Polyamine Oxidase (PAOX) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Polyamine Oxidase (PAOX) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Polyamine Oxidase (PAOX) CLIA Kit Customized Service Offer
n/a ELISA Kit for Polyamine Oxidase (PAOX) ELISA Kit Customized Service Offer
  1. "Cloning, sequencing, and heterologous expression of the murine peroxisomal flavoprotein, N(1)-acetylated polyamine oxidase."J. Biol. Chem. 278:20514-20525(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion."Biochem. J. 370:19-28(2003) [PubMed] [Europe PMC] [Abstract]
  7. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]