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Glycine-N-Methyltransferase (GNMT)

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Glycine-N-Methyltransferase (GNMT)
CCC G820
HGNC 4415
MGI 1202304
PubMed 22687285
RGD 2719
UniProt Q14749
Wiki GNMT
Glycine N-methyltransferase (GNMT; EC 2.1.1.20) catalyzes the synthesis of N-methylglycine (sarcosine) from glycine using S-adenosylmethionine (AdoMet) as the methyl donor.GNMT acts as an enzyme to regulate the ratio of S-adenosylmethionine to S-adenosylhomocysteine (AdoHcy) and participates in the detoxification pathway in liver cells.
These unbiased metabolomic profiles were able to distinguish benign prostate, clinically localized prostate cancer, and metastatic disease. Sarcosine, an N-methyl derivative of the amino acid glycine, was identified as a differential metabolite that is highly increased during prostate cancer progression to metastasis and can be detected noninvasively in urine. Sarcosine levels were also increased in invasive prostate cancer cell lines relative to benign prostate epithelial cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG820Hu01 Recombinant Glycine-N-Methyltransferase (GNMT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG820Hu01 Polyclonal Antibody to Glycine-N-Methyltransferase (GNMT) WB; IHC; ICC; IP.
MAG820Hu21 Monoclonal Antibody to Glycine-N-Methyltransferase (GNMT) WB; IHC; ICC; IP.
Assay Kits SEG820Hu ELISA Kit for Glycine-N-Methyltransferase (GNMT) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glycine-N-Methyltransferase (GNMT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glycine-N-Methyltransferase (GNMT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glycine-N-Methyltransferase (GNMT) Polyclonal Antibody Customized Service Offer
Assay Kits SEG820Mu ELISA Kit for Glycine-N-Methyltransferase (GNMT) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glycine-N-Methyltransferase (GNMT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glycine-N-Methyltransferase (GNMT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glycine-N-Methyltransferase (GNMT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glycine-N-Methyltransferase (GNMT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glycine-N-Methyltransferase (GNMT) ELISA Kit Customized Service Offer
  1. "Characterization of glycine-N-methyltransferase-gene expression in human hepatocellular carcinoma."Int. J. Cancer 75:787-793(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic structure, expression, and chromosomal localization of the human glycine N-methyltransferase gene."Genomics 66:43-47(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Mammalian glycine N-methyltransferases. Comparative kinetic and structural properties of the enzymes from human, rat, rabbit and pig livers."Comp. Biochem. Physiol. 106B:601-611(1993) [PubMed] [Europe PMC] [Abstract]
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  7. "Glycine N-methyltransferases: a comparison of the crystal structures and kinetic properties of recombinant human, mouse and rat enzymes."Proteins 57:331-337(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Destabilization of human glycine N-methyltransferase by H176N mutation."Protein Sci. 16:1957-1964(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Mutations in human glycine N-methyltransferase give insights into its role in methionine metabolism."Hum. Genet. 110:68-74(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Effect of naturally occurring mutations in human glycine N-methyltransferase on activity and conformation."Biochem. Biophys. Res. Commun. 312:1067-1072(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Glycine N-methyltransferase deficiency: a new patient with a novel mutation."J. Inherit. Metab. Dis. 26:745-759(2003) [PubMed] [Europe PMC] [Abstract]