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Cytidine Triphosphate Synthase (CTPS)

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CTPS1; CTP Synthase 1; UTP--ammonia ligase 1; CTP synthetase 1

Cytidine Triphosphate Synthase (CTPS)
CCC G826
HGNC 2519
MGI 1858304
PubMed 20375368
RGD 1311060
UniProt P17812
Wiki CTPS
The catalytic conversion of UTP to CTP is accomplished by the enzyme cytidine-5-prime-triphosphate synthetase (UTP:L-glutamine amido ligase; EC 6.3.4.2). The enzyme is important in the biosynthesis of phospholipids and nucleic acids, and plays a key role in cell growth, development, and tumorigenesis. Thomas et al. (1989) isolated a cDNA clone of the CTP synthetase gene from a rat liver cDNA library. It is a key regulatory enzyme in pyrimidine biosynthesis. These authors have isolated both cDNA and genomic gene sequences from the rat and Chinese hamster.
Yamauchi et al. (1990) cloned the CTPS gene and showed that the open reading frame encodes 591 amino acids that have a striking degree of similarity to the structural gene in E. coli.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytidine Triphosphate Synthase (CTPS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytidine Triphosphate Synthase (CTPS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytidine Triphosphate Synthase (CTPS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytidine Triphosphate Synthase (CTPS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytidine Triphosphate Synthase (CTPS) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytidine Triphosphate Synthase (CTPS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytidine Triphosphate Synthase (CTPS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytidine Triphosphate Synthase (CTPS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytidine Triphosphate Synthase (CTPS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytidine Triphosphate Synthase (CTPS) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytidine Triphosphate Synthase (CTPS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytidine Triphosphate Synthase (CTPS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytidine Triphosphate Synthase (CTPS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytidine Triphosphate Synthase (CTPS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytidine Triphosphate Synthase (CTPS) ELISA Kit Customized Service Offer
  1. "Molecular cloning of the human CTP synthetase gene by functional complementation with purified human metaphase chromosomes."EMBO J. 9:2095-2099(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Expression of human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A."J. Biol. Chem. 280:38328-38336(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line."Electrophoresis 28:2027-2034(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  19. "CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation."Nature 510:288-292(2014) [PubMed] [Europe PMC] [Abstract]
  20. "Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy."Acta Crystallogr. F 62:613-617(2006) [PubMed] [Europe PMC] [Abstract]