≡

Inositol-1,4,5-Trisphosphate-3-Kinase B (ITPKB)

[Edit]

ITPK-B; IP3K; IP3K-B; PIG37

Inositol-1,4,5-Trisphosphate-3-Kinase B (ITPKB)
CCC G828
HGNC 6179
MGI 109235
PubMed 22981169
RGD 2932
UniProt P27987
Wiki ITPKB
ITPKB regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity.
Sequencing yielded an open reading frame encoding a 472-amino acid protein with a calculated relative mass of 53,451. The C-terminal part of ITPKB, namely residues 187 to 462, was 68% identical to ITPKA in amino acid sequence.Mitogenic stimulation of thymocytes resulted in decreased Ins(1,3,4,5)P4, but not Ins(3,4,5)P3, production.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inositol-1,4,5-Trisphosphate-3-Kinase B (ITPKB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inositol-1,4,5-Trisphosphate-3-Kinase B (ITPKB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inositol-1,4,5-Trisphosphate-3-Kinase B (ITPKB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inositol-1,4,5-Trisphosphate-3-Kinase B (ITPKB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inositol-1,4,5-Trisphosphate-3-Kinase B (ITPKB) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inositol-1,4,5-Trisphosphate-3-Kinase B (ITPKB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inositol-1,4,5-Trisphosphate-3-Kinase B (ITPKB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inositol-1,4,5-Trisphosphate-3-Kinase B (ITPKB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inositol-1,4,5-Trisphosphate-3-Kinase B (ITPKB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inositol-1,4,5-Trisphosphate-3-Kinase B (ITPKB) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inositol-1,4,5-Trisphosphate-3-Kinase B (ITPKB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inositol-1,4,5-Trisphosphate-3-Kinase B (ITPKB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inositol-1,4,5-Trisphosphate-3-Kinase B (ITPKB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inositol-1,4,5-Trisphosphate-3-Kinase B (ITPKB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inositol-1,4,5-Trisphosphate-3-Kinase B (ITPKB) ELISA Kit Customized Service Offer
  1. "Cloning and expression of a full-length cDNA encoding human inositol 1,4,5-trisphosphate 3-kinase B."Biochem. Biophys. Res. Commun. 291:400-405(2002) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Molecular cloning and expression of a new putative inositol 1,4,5-trisphosphate 3-kinase isoenzyme."Biochem. J. 278:883-886(1991) [PubMed] [Europe PMC] [Abstract]
  5. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Headpiece domain of dematin regulates calcium mobilization and signaling in platelets."J. Biol. Chem. 287:41218-41231(2012) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]