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Myo Inositol Oxygenase (MIOX)

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ALDRL6; KSP32; RSOR; Kidney-Specific Protein 32; Aldehyde Reductase(Aldose Reductase)Like 6; Renal-specific oxidoreductase; Myo-inositol oxygenase

Myo Inositol Oxygenase (MIOX)
CCC G831
HGNC 14522
MGI 1891725
RGD 628739
UniProt Q9UGB7
Aldo-keto reductases are widely distributed in mammalian tissues. ALDRL6, or myoinositol oxygenase (EC 1.13.99.1), is a renal-specific member of this family and catalyzes the first committed step in the only pathway of myoinositol metabolism. ALDRL6 has been implicated in complications of diabetes, including diabetic nephropathy.
Aldrl6 expression in mouse is confined to renal proximal tubules, with upregulated expression in diabetic kidneys. In situ hybridization of mouse kidney sections revealed exclusive expression in renal tubules of the kidney cortex.ALDRL6 shares 91% sequence identity with mouse Aldrl6 and 96% sequence similarity with the pig homolog .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG831Hu01 Recombinant Myo Inositol Oxygenase (MIOX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG831Hu01 Polyclonal Antibody to Myo Inositol Oxygenase (MIOX) WB; IHC; ICC; IP.
MAG831Hu21 Monoclonal Antibody to Myo Inositol Oxygenase (MIOX) WB; IHC; ICC; IP.
Assay Kits SEG831Hu ELISA Kit for Myo Inositol Oxygenase (MIOX) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myo Inositol Oxygenase (MIOX) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myo Inositol Oxygenase (MIOX) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myo Inositol Oxygenase (MIOX) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myo Inositol Oxygenase (MIOX) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myo Inositol Oxygenase (MIOX) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myo Inositol Oxygenase (MIOX) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myo Inositol Oxygenase (MIOX) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myo Inositol Oxygenase (MIOX) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myo Inositol Oxygenase (MIOX) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myo Inositol Oxygenase (MIOX) ELISA Kit Customized Service Offer
  1. "Identification of a renal-specific oxido-reductase in newborn diabetic mice."Proc. Natl. Acad. Sci. U.S.A. 97:9896-9901(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning, expression, and characterization of myo-inositol oxygenase from mouse, rat, and human kidney."Biochem. Biophys. Res. Commun. 324:1386-1392(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Structural and biophysical characterization of human myo-inositol oxygenase."J. Biol. Chem. 283:15209-15216(2008) [PubMed] [Europe PMC] [Abstract]