≡

Inositol Polyphosphate Phosphatase Like Protein 1 (INPPL1)

[Edit]

SHIP2; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatase 2; 51C Protein; SH2 domain-containing inositol 5'-phosphatase 2

Inositol Polyphosphate Phosphatase Like Protein 1 (INPPL1)
CCC G837
HGNC 6080
MGI 1333787
PubMed 23273569
RGD 68396
UniProt O15357
Wiki INPPL1
INPPL1 encodes inositol polyphosphate-5 phosphatase-like 1, a protein that in addition to the phosphatase domain contains an SH2 (src-homology domain 2) motif.SHIP2 encodes a 1,258-amino acid protein with a predicted molecular mass of 142 kD. SHIP2 was also expressed in dog thyroid cells in primary culture, where the expression was enhanced in thyroid-stimulating hormone (TSH)- and epidermal growth factor (EGF)-stimulated cells.The SHIP2 antiserum precipitated a protein of approximately 145 kD, along with an activity which hydrolyzed phosphatidylinositol 3,4,5-triphosphate to phosphatidylinositol 3,4-bisphosphate. Tyrosine phosphorylation of SHIP2 occurred in response to treatment of cells with EGF, platelet-derived growth factor (PDGF), nerve growth factor (NGF), insulin-like growth factor-1 (IGF1), or insulin.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inositol Polyphosphate Phosphatase Like Protein 1 (INPPL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inositol Polyphosphate Phosphatase Like Protein 1 (INPPL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inositol Polyphosphate Phosphatase Like Protein 1 (INPPL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inositol Polyphosphate Phosphatase Like Protein 1 (INPPL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inositol Polyphosphate Phosphatase Like Protein 1 (INPPL1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inositol Polyphosphate Phosphatase Like Protein 1 (INPPL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inositol Polyphosphate Phosphatase Like Protein 1 (INPPL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inositol Polyphosphate Phosphatase Like Protein 1 (INPPL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inositol Polyphosphate Phosphatase Like Protein 1 (INPPL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inositol Polyphosphate Phosphatase Like Protein 1 (INPPL1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inositol Polyphosphate Phosphatase Like Protein 1 (INPPL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inositol Polyphosphate Phosphatase Like Protein 1 (INPPL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inositol Polyphosphate Phosphatase Like Protein 1 (INPPL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inositol Polyphosphate Phosphatase Like Protein 1 (INPPL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inositol Polyphosphate Phosphatase Like Protein 1 (INPPL1) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of a human cDNA (INPPL1) sharing homology with inositol polyphosphate phosphatases."Genomics 29:285-287(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of a second SH2-domain-containing protein closely related to the phosphatidylinositol polyphosphate 5-phosphatase SHIP."Biochem. Biophys. Res. Commun. 239:697-700(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 protein."J. Biol. Chem. 273:18605-18609(1998) [PubMed] [Europe PMC] [Abstract]
  6. "A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells."Blood 93:2707-2720(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Molecular basis of the recruitment of the SH2 domain-containing inositol 5-phosphatases SHIP1 and SHIP2 by fcgamma RIIB."J. Biol. Chem. 275:37357-37364(2000) [PubMed] [Europe PMC] [Abstract]
  8. "The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cells."J. Biol. Chem. 276:28348-28355(2001) [PubMed] [Europe PMC] [Abstract]
  9. "The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin."J. Cell Biol. 155:1065-1079(2001) [PubMed] [Europe PMC] [Abstract]
  10. "SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading."Mol. Cell. Biol. 21:1416-1428(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway."J. Biol. Chem. 277:1031-1039(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Src family tyrosine kinases regulate adhesion-dependent tyrosine phosphorylation of 5'-inositol phosphatase SHIP2 during cell attachment and spreading on collagen I."J. Cell Sci. 115:3807-3815(2002) [PubMed] [Europe PMC] [Abstract]
  13. "The c-Cbl-associated protein and c-Cbl are two new partners of the SH2-containing inositol polyphosphate 5-phosphatase SHIP2."Biochem. Biophys. Res. Commun. 300:494-500(2003) [PubMed] [Europe PMC] [Abstract]
  14. "SHIP-2 forms a tetrameric complex with filamin, actin, and GPIb-IX-V: localization of SHIP-2 to the activated platelet actin cytoskeleton."Blood 102:940-948(2003) [PubMed] [Europe PMC] [Abstract]
  15. "SHIP-2 inositol phosphatase is inducibly expressed in human monocytes and serves to regulate Fcgamma receptor-mediated signaling."J. Biol. Chem. 278:22657-22663(2003) [PubMed] [Europe PMC] [Abstract]
  16. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  17. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  18. "The influence of anionic lipids on SHIP2 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase activity."Cell. Signal. 18:2193-2199(2006) [PubMed] [Europe PMC] [Abstract]
  19. "SHIP2 interaction with the cytoskeletal protein Vinexin."FEBS J. 272:6052-6066(2005) [PubMed] [Europe PMC] [Abstract]
  20. "SH2-containing 5'-inositol phosphatase, SHIP2, regulates cytoskeleton organization and ligand-dependent down-regulation of the epidermal growth factor receptor."J. Biol. Chem. 280:13129-13136(2005) [PubMed] [Europe PMC] [Abstract]
  21. "The SH2-domain-containing inositol 5-phosphatase (SHIP)-2 binds to c-Met directly via tyrosine residue 1356 and involves hepatocyte growth factor (HGF)-induced lamellipodium formation, cell scattering and cell spreading."Oncogene 24:3436-3447(2005) [PubMed] [Europe PMC] [Abstract]
  22. "The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner."Cell. Signal. 19:1249-1257(2007) [PubMed] [Europe PMC] [Abstract]
  23. "Regulation of EphA2 receptor endocytosis by SHIP2 lipid phosphatase via phosphatidylinositol 3-Kinase-dependent Rac1 activation."J. Biol. Chem. 282:2683-2694(2007) [PubMed] [Europe PMC] [Abstract]
  24. "Regulation of PDGF-stimulated SHIP2 tyrosine phosphorylation and association with Shc in 3T3-L1 preadipocytes."J. Cell. Physiol. 211:598-607(2007) [PubMed] [Europe PMC] [Abstract]
  25. "The gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man."Diabetes 51:2012-2017(2002) [PubMed] [Europe PMC] [Abstract]
  26. "Polymorphisms in type II SH2 domain-containing inositol 5-phosphatase (INPPL1, SHIP2) are associated with physiological abnormalities of the metabolic syndrome."Diabetes 53:1900-1904(2004) [PubMed] [Europe PMC] [Abstract]
  27. "Impact of SRC homology 2-containing inositol 5'-phosphatase 2 gene polymorphisms detected in a Japanese population on insulin signaling."J. Clin. Endocrinol. Metab. 90:2911-2919(2005) [PubMed] [Europe PMC] [Abstract]
  28. "Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension."J. Med. Genet. 44:603-605(2007) [PubMed] [Europe PMC] [Abstract]
  29. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  30. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  31. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  32. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  33. "Exome sequencing identifies INPPL1 mutations as a cause of opsismodysplasia."Am. J. Hum. Genet. 92:144-149(2013) [PubMed] [Europe PMC] [Abstract]