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Multiple Inositol Polyphosphate Phosphatase 1 (MINPP1)

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HIPER1; MINPP2; MIPP; Multiple Inositol Polyphosphate Histidine Phosphatase, 1; 2,3-bisphosphoglycerate 3-phosphatase; Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase

Multiple Inositol Polyphosphate Phosphatase 1 (MINPP1)
CCC G838
HGNC 7102
MGI 1336159
PubMed 10938126
RGD 3089
UniProt Q9UNW1
Wiki MINPP1
MINPP1 encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway.Sequence analysis predicted that the 487-amino acid MINPP1 protein is 84% identical to rat Mipp and about 53% identical to chick HiPER1. The N terminus of MINPP1 contains an ER-targeting domain consisting of a relatively long net-positive-charge (n) region, a hydrophobic core region, and a recognition site for signal peptidases.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Multiple Inositol Polyphosphate Phosphatase 1 (MINPP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Multiple Inositol Polyphosphate Phosphatase 1 (MINPP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Multiple Inositol Polyphosphate Phosphatase 1 (MINPP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Multiple Inositol Polyphosphate Phosphatase 1 (MINPP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Multiple Inositol Polyphosphate Phosphatase 1 (MINPP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Multiple Inositol Polyphosphate Phosphatase 1 (MINPP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Multiple Inositol Polyphosphate Phosphatase 1 (MINPP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Multiple Inositol Polyphosphate Phosphatase 1 (MINPP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Multiple Inositol Polyphosphate Phosphatase 1 (MINPP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Multiple Inositol Polyphosphate Phosphatase 1 (MINPP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Multiple Inositol Polyphosphate Phosphatase 1 (MINPP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Multiple Inositol Polyphosphate Phosphatase 1 (MINPP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Multiple Inositol Polyphosphate Phosphatase 1 (MINPP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Multiple Inositol Polyphosphate Phosphatase 1 (MINPP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Multiple Inositol Polyphosphate Phosphatase 1 (MINPP1) ELISA Kit Customized Service Offer
  1. "The human and rat forms of multiple inositol polyphosphate phosphatase: functional homology with a histidine acid phosphatase up-regulated during endochondral ossification."FEBS Lett. 442:99-104(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19."Genomics 56:324-336(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Dephosphorylation of 2,3-bisphosphoglycerate by MIPP expands the regulatory capacity of the Rapoport-Luebering glycolytic shunt."Proc. Natl. Acad. Sci. U.S.A. 105:5998-6003(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Somatic mutation and germline variants of MINPP1, a phosphatase gene located in proximity to PTEN on 10q23.3, in follicular thyroid carcinomas."J. Clin. Endocrinol. Metab. 86:1801-1805(2001) [PubMed] [Europe PMC] [Abstract]