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Phosphatidylinositol-5-Phosphate-4-Kinase Type II Alpha (PIP4K2a)

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PIP5KII-alpha; PIPK; 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha; Diphosphoinositide kinase 2-alpha

Phosphatidylinositol-5-Phosphate-4-Kinase Type II Alpha (PIP4K2a)
CCC G845
HGNC 8997
MGI 1298206
PubMed 23744494
RGD 621708
UniProt P48426
Wiki PIP4K2A
Phosphatidylinositol-4,5-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility.
PIP4K2a is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-4-phosphate on the fifth hydroxyl of the myo-inositol ring to form phosphatidylinositol-4,5-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-4-phosphate 5-kinase family.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylinositol-5-Phosphate-4-Kinase Type II Alpha (PIP4K2a) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylinositol-5-Phosphate-4-Kinase Type II Alpha (PIP4K2a) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylinositol-5-Phosphate-4-Kinase Type II Alpha (PIP4K2a) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylinositol-5-Phosphate-4-Kinase Type II Alpha (PIP4K2a) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylinositol-5-Phosphate-4-Kinase Type II Alpha (PIP4K2a) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylinositol-5-Phosphate-4-Kinase Type II Alpha (PIP4K2a) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylinositol-5-Phosphate-4-Kinase Type II Alpha (PIP4K2a) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylinositol-5-Phosphate-4-Kinase Type II Alpha (PIP4K2a) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylinositol-5-Phosphate-4-Kinase Type II Alpha (PIP4K2a) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylinositol-5-Phosphate-4-Kinase Type II Alpha (PIP4K2a) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylinositol-5-Phosphate-4-Kinase Type II Alpha (PIP4K2a) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylinositol-5-Phosphate-4-Kinase Type II Alpha (PIP4K2a) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylinositol-5-Phosphate-4-Kinase Type II Alpha (PIP4K2a) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylinositol-5-Phosphate-4-Kinase Type II Alpha (PIP4K2a) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylinositol-5-Phosphate-4-Kinase Type II Alpha (PIP4K2a) ELISA Kit Customized Service Offer
  1. "The sequence of phosphatidylinositol-4-phosphate 5-kinase defines a novel family of lipid kinases."J. Biol. Chem. 270:2881-2884(1995) [PubMed] [Europe PMC] [Abstract]
  2. "The cloning and sequence of the C isoform of PtdIns4P 5-kinase."Biochem. J. 309:715-719(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate."Nature 390:192-196(1997) [PubMed] [Europe PMC] [Abstract]
  7. "Regulation of extranuclear PtdIns5P production by phosphatidylinositol phosphate 4-kinase 2alpha."FEBS Lett. 582:1391-1394(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  12. "PIP4Kbeta interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kalpha."Biochem. J. 430:223-235(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Localization, regulation and function of type II phosphatidylinositol 5-phosphate 4-kinases."Adv. Enzyme Regul. 50:12-18(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]