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Phosphatidylinositol-5-Phosphate-4-Kinase Type II Beta (PIP4K2b)

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PIP5KIIB; Pip4k2B; PIP5K2B; 1-phosphatidylinositol 5-phosphate 4-kinase 2-beta; Diphosphoinositide kinase 2-beta; PtdIns(5)P-4-kinase isoform 2-beta

Phosphatidylinositol-5-Phosphate-4-Kinase Type II Beta (PIP4K2b)
CCC G846
HGNC 8998
MGI 1934234
PubMed 24127122
RGD 621710
UniProt P78356
Wiki PIP4K2B
PIP4K2b catalyzes the phosphorylation of phosphatidylinositol-4-phosphate on the fifth hydroxyl of the myo-inositol ring to form phosphatidylinositol-4,5-bisphosphate. This gene is a member of the phosphatidylinositol-4-phosphate 5-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor.
The deduced 416-amino acid protein is 78% identical to PIP5K2A. Using SDS-PAGE, the authors estimated that bacterially expressed PIP5K2B has a molecular mass of 47 kD. Northern blot analysis detected a 6.3-kb PIP5K2B transcript which was abundantly expressed in several human tissues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylinositol-5-Phosphate-4-Kinase Type II Beta (PIP4K2b) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylinositol-5-Phosphate-4-Kinase Type II Beta (PIP4K2b) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylinositol-5-Phosphate-4-Kinase Type II Beta (PIP4K2b) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylinositol-5-Phosphate-4-Kinase Type II Beta (PIP4K2b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylinositol-5-Phosphate-4-Kinase Type II Beta (PIP4K2b) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylinositol-5-Phosphate-4-Kinase Type II Beta (PIP4K2b) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylinositol-5-Phosphate-4-Kinase Type II Beta (PIP4K2b) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylinositol-5-Phosphate-4-Kinase Type II Beta (PIP4K2b) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylinositol-5-Phosphate-4-Kinase Type II Beta (PIP4K2b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylinositol-5-Phosphate-4-Kinase Type II Beta (PIP4K2b) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylinositol-5-Phosphate-4-Kinase Type II Beta (PIP4K2b) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylinositol-5-Phosphate-4-Kinase Type II Beta (PIP4K2b) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylinositol-5-Phosphate-4-Kinase Type II Beta (PIP4K2b) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylinositol-5-Phosphate-4-Kinase Type II Beta (PIP4K2b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylinositol-5-Phosphate-4-Kinase Type II Beta (PIP4K2b) ELISA Kit Customized Service Offer
  1. "A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase."J. Biol. Chem. 272:5861-5870(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  4. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  7. "PIP4Kbeta interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kalpha."Biochem. J. 430:223-235(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation."Cell 94:829-839(1998) [PubMed] [Europe PMC] [Abstract]