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Phosphatidylinositol-4-Phosphate-5-Kinase Type I Alpha (PIP5K1a)

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68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha; Phosphatidylinositol 4-phosphate 5-kinase type I alpha

Phosphatidylinositol-4-Phosphate-5-Kinase Type I Alpha (PIP5K1a)
CCC G847
HGNC 8994
MGI 107929
PubMed 22321832
UniProt Q99755
Wiki PIP5K1A
Phosphatidylinositol-4-phosphate 5-kinases synthesize phosphatidylinositol 4,5-bisphosphate by phosphorylating phosphatidylinositol 4-phosphate.
The deduced 549-amino acid protein has the conserved kinase homology domain of PIP5K family members. Within this domain, PIP5K1A shows 83% and 35% amino acid identity with PIP5K1B and PIP5K2A , respectively. Overall, the PIP5K1A and PIP5K1B proteins are 64% identical. Recombinant PIP5K1A expressed in bacteria had a molecular mass of approximately 66.3 kD. The authors isolated additional PIP5K1A cDNAs which they suggested represent splicing isoforms. Northern blot analysis detected a major 4.2-kb PIP5K1A transcript which had a wide tissue distribution.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylinositol-4-Phosphate-5-Kinase Type I Alpha (PIP5K1a) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylinositol-4-Phosphate-5-Kinase Type I Alpha (PIP5K1a) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylinositol-4-Phosphate-5-Kinase Type I Alpha (PIP5K1a) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylinositol-4-Phosphate-5-Kinase Type I Alpha (PIP5K1a) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylinositol-4-Phosphate-5-Kinase Type I Alpha (PIP5K1a) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylinositol-4-Phosphate-5-Kinase Type I Alpha (PIP5K1a) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylinositol-4-Phosphate-5-Kinase Type I Alpha (PIP5K1a) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylinositol-4-Phosphate-5-Kinase Type I Alpha (PIP5K1a) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylinositol-4-Phosphate-5-Kinase Type I Alpha (PIP5K1a) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylinositol-4-Phosphate-5-Kinase Type I Alpha (PIP5K1a) ELISA Kit Customized Service Offer
  1. "Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family."J. Biol. Chem. 271:32937-32943(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls expression of select mRNAs."Nature 451:1013-1017(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Phosphatidylinositol-4-phosphate 5-kinase 1alpha mediates extracellular calcium-induced keratinocyte differentiation."Mol. Biol. Cell 20:1695-1704(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Type I PIPK-alpha regulates directed cell migration by modulating Rac1 plasma membrane targeting and activation."J. Cell Biol. 190:247-262(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]