Deoxycytidine Triphosphate Pyrophosphatase 1 (DCTPP1)

dCTP pyrophosphatase 1 is an enzyme encoded by the DCTPP1 gene. Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that is used whenever DNA is synthesized, such as in the polymerase chain reaction. That is, dCTP has the PP_i (pyrophosphate) cleaved off and the dCMP is incorporated into the DNA strand at the 3' end. Subsequent hydrolysis of the PP_i drives the equilibrium of the reaction toward the right side, i.e. incorporation of the nucleotide in the growing DNA chain. Pyrophosphatase is an enzyme that converts one molecule of pyrophosphate to two phosphate ions. This highly exergonic reaction can be coupled to unfavorable biochemical transformations in order to drive these transformations to completion, as in lipid synthesis and other biochemical transformations.