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WNT1 Inducible Signaling Pathway Protein 2 (WISP2)

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CCN5; CT58; CTGF-L; CCN family member 5; Connective tissue growth factor-like protein; Connective tissue growth factor-related protein 58

WNT1 Inducible Signaling Pathway Protein 2 (WISP2)
CCC G894
HGNC 12770
MGI 1328326
RGD 621867
UniProt O76076
WISP2 encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes.
The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG894Hu01 Recombinant WNT1 Inducible Signaling Pathway Protein 2 (WISP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG894Hu01 Polyclonal Antibody to WNT1 Inducible Signaling Pathway Protein 2 (WISP2) WB; IHC; ICC; IP.
LAG894Hu71 Biotin-Linked Polyclonal Antibody to WNT1 Inducible Signaling Pathway Protein 2 (WISP2) WB; IHC; ICC.
MAG894Hu21 Monoclonal Antibody to WNT1 Inducible Signaling Pathway Protein 2 (WISP2) WB; IHC; ICC; IP.
Assay Kits SEG894Hu ELISA Kit for WNT1 Inducible Signaling Pathway Protein 2 (WISP2) Enzyme-linked immunosorbent assay for Antigen Detection.
SCG894Hu CLIA Kit for WNT1 Inducible Signaling Pathway Protein 2 (WISP2) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG894Mu01 Recombinant WNT1 Inducible Signaling Pathway Protein 2 (WISP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG894Mu01 Polyclonal Antibody to WNT1 Inducible Signaling Pathway Protein 2 (WISP2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for WNT1 Inducible Signaling Pathway Protein 2 (WISP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for WNT1 Inducible Signaling Pathway Protein 2 (WISP2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG894Ra01 Recombinant WNT1 Inducible Signaling Pathway Protein 2 (WISP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG894Ra01 Polyclonal Antibody to WNT1 Inducible Signaling Pathway Protein 2 (WISP2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for WNT1 Inducible Signaling Pathway Protein 2 (WISP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for WNT1 Inducible Signaling Pathway Protein 2 (WISP2) ELISA Kit Customized Service Offer
  1. "Identification and cloning of a connective tissue growth factor-like cDNA from human osteoblasts encoding a novel regulator of osteoblast functions."J. Biol. Chem. 274:17123-17131(1999) [PubMed] [Europe PMC] [Abstract]
  2. "WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors."Proc. Natl. Acad. Sci. U.S.A. 95:14717-14722(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]