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Uracil DNA Glycosylase (UNG)

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UDG, UNG1, UNG2, HIGM4

Uracil DNA Glycosylase (UNG)
CCC G917
HGNC 12572
MGI 109352
PubMed 10912000
RGD 1307200
UniProt P13051
Wiki UNG
UNG encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the nuclear (UNG2) and mitochondrial (UNG1) isoforms of UNG result from alternative splicing and the use of alternative promoters. The UNG1 and UNG2 proteins contain different N-terminal sequences, but the downstream 269 amino acids are common and include a short region that binds replication protein A and a larger, compact catalytic domain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG917Hu01 Recombinant Uracil DNA Glycosylase (UNG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG917Hu01 Polyclonal Antibody to Uracil DNA Glycosylase (UNG) WB; IHC; ICC/IF
MAG917Hu21 Monoclonal Antibody to Uracil DNA Glycosylase (UNG) WB; IHC; ICC; IP.
Assay Kits SEG917Hu ELISA Kit for Uracil DNA Glycosylase (UNG) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Uracil DNA Glycosylase (UNG) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Uracil DNA Glycosylase (UNG) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Uracil DNA Glycosylase (UNG) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Uracil DNA Glycosylase (UNG) CLIA Kit Customized Service Offer
n/a ELISA Kit for Uracil DNA Glycosylase (UNG) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Uracil DNA Glycosylase (UNG) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Uracil DNA Glycosylase (UNG) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Uracil DNA Glycosylase (UNG) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Uracil DNA Glycosylase (UNG) CLIA Kit Customized Service Offer
n/a ELISA Kit for Uracil DNA Glycosylase (UNG) ELISA Kit Customized Service Offer
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  2. "Structure of the gene for human uracil-DNA glycosylase and analysis of the promoter function."FEBS Lett. 353:180-184(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene."Nucleic Acids Res. 25:750-755(1997) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Nuclear and mitochondrial forms of human uracil-DNA glycosylase are encoded by the same gene."Nucleic Acids Res. 21:2579-2584(1993) [PubMed] [Europe PMC] [Abstract]
  7. "Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase."EMBO J. 15:3442-3447(1996) [PubMed] [Europe PMC] [Abstract]
  8. "Human immunodeficiency virus type 1 Vpr protein binds to the uracil DNA glycosylase DNA repair enzyme."J. Virol. 70:697-704(1996) [PubMed] [Europe PMC] [Abstract]
  9. "Nuclear and mitochondrial splice forms of human uracil-DNA glycosylase contain a complex nuclear localisation signal and a strong classical mitochondrial localisation signal, respectively."Nucleic Acids Res. 26:4611-4617(1998) [PubMed] [Europe PMC] [Abstract]
  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Ugene, a newly identified protein that is commonly overexpressed in cancer and binds uracil DNA glycosylase."Cancer Res. 68:6118-6126(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Crystal structure and mutational analysis of human uracil-DNA glycosylase: structural basis for specificity and catalysis."Cell 80:869-878(1995) [PubMed] [Europe PMC] [Abstract]
  20. "Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor: protein mimicry of DNA."Cell 82:701-708(1995) [PubMed] [Europe PMC] [Abstract]
  21. "A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA."Nature 384:87-92(1996) [PubMed] [Europe PMC] [Abstract]
  22. "Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA."EMBO J. 17:5214-5226(1998) [PubMed] [Europe PMC] [Abstract]
  23. "Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination."Nat. Immunol. 4:1023-1028(2003) [PubMed] [Europe PMC] [Abstract]
  24. "B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil."J. Exp. Med. 201:2011-2021(2005) [PubMed] [Europe PMC] [Abstract]