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UDP Glucuronosyltransferase 2 Family, Polypeptide B7 (UGT2B7)

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UGTB2B9; UDPGTh-2; 3,4-catechol estrogen-specific UDPGT

UDP Glucuronosyltransferase 2 Family, Polypeptide B7 (UGT2B7)
CCC G932
HGNC 12554
PubMed 18622263
RGD 708417
UniProt P16662
Wiki UGT2B7
UGT2B7 is a phase II metabolism isoenzyme found to be active in the liver, kidneys, epithelial cells of the lower gastrointestinal tract and also has been reported in the brain. UGT2B7 is capable of glucosidation of hyodesoxycholic acid in the liver, but unlike the 2B4 isoform, 2B7 is also able to glucuronidate various steroid hormones and fatty acids. It is also able to conjugate major classes of drugs such as analgesics (morphine), carboxylic nonsteroidal anti-inflammatory drugs (ketoprofen) and anticarcinogens. UGT2B7 is the major enzyme isoform for the metabolism of morphine to the main metabolites, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G), and consequently altered UGT2B7 activity can significantly affect both the effectiveness and side effects of morphine, as well as some related opiate drugs.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG932Hu01 Recombinant UDP Glucuronosyltransferase 2 Family, Polypeptide B7 (UGT2B7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG932Hu21 Monoclonal Antibody to UDP Glucuronosyltransferase 2 Family, Polypeptide B7 (UGT2B7) WB; IHC; ICC; IP.
PAG932Hu01 Polyclonal Antibody to UDP Glucuronosyltransferase 2 Family, Polypeptide B7 (UGT2B7) WB; IHC; ICC; IP.
Assay Kits SEG932Hu ELISA Kit for UDP Glucuronosyltransferase 2 Family, Polypeptide B7 (UGT2B7) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG932Ra01 Recombinant UDP Glucuronosyltransferase 2 Family, Polypeptide B7 (UGT2B7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG932Ra21 Monoclonal Antibody to UDP Glucuronosyltransferase 2 Family, Polypeptide B7 (UGT2B7) WB; IHC; ICC; IP.
PAG932Ra01 Polyclonal Antibody to UDP Glucuronosyltransferase 2 Family, Polypeptide B7 (UGT2B7) WB; IHC; ICC; IP.
Assay Kits SEG932Ra ELISA Kit for UDP Glucuronosyltransferase 2 Family, Polypeptide B7 (UGT2B7) Enzyme-linked immunosorbent assay for Antigen Detection.
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  7. "Crystal structure of the cofactor-binding domain of the human phase II drug-metabolism enzyme UDP-glucuronosyltransferase 2B7."J. Mol. Biol. 369:498-511(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268: ethnic diversity of alleles and potential clinical significance."Pharmacogenetics 10:679-685(2000) [PubMed] [Europe PMC] [Abstract]