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UDP Glucose-6-Dehydrogenase (UGDH)

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GDH; UDP-GlcDH; UDPGDH; UGD

UDP Glucose-6-Dehydrogenase (UGDH)
CCC G938
HGNC 12525
MGI 1306785
PubMed 16292757
RGD 621879
UniProt O60701
Wiki UGDH
UGDH encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia.
The predicted 494-amino acid human protein is 1 amino acid longer than mouse Udpgdh, and the 2 proteins are 98% identical. Both the human and mouse cDNAs contained at least 2 consensus polyadenylation sequences.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant UDP Glucose-6-Dehydrogenase (UGDH) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to UDP Glucose-6-Dehydrogenase (UGDH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to UDP Glucose-6-Dehydrogenase (UGDH) Polyclonal Antibody Customized Service Offer
Assay Kits SEG938Hu ELISA Kit for UDP Glucose-6-Dehydrogenase (UGDH) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant UDP Glucose-6-Dehydrogenase (UGDH) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to UDP Glucose-6-Dehydrogenase (UGDH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to UDP Glucose-6-Dehydrogenase (UGDH) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for UDP Glucose-6-Dehydrogenase (UGDH) CLIA Kit Customized Service Offer
n/a ELISA Kit for UDP Glucose-6-Dehydrogenase (UGDH) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant UDP Glucose-6-Dehydrogenase (UGDH) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to UDP Glucose-6-Dehydrogenase (UGDH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to UDP Glucose-6-Dehydrogenase (UGDH) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for UDP Glucose-6-Dehydrogenase (UGDH) CLIA Kit Customized Service Offer
n/a ELISA Kit for UDP Glucose-6-Dehydrogenase (UGDH) ELISA Kit Customized Service Offer
  1. "Molecular cloning and characterization of the human and mouse UDP-glucose dehydrogenase genes."J. Biol. Chem. 273:25117-25124(1998) [PubMed] [Europe PMC] [Abstract]
  2. "cDNA cloning and expression analysis of the human UDPglucose dehydrogenase."Proc. Natl. Sci. Counc. Repub. China, B, Life Sci. 22:166-172(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Structural and kinetic evidence that catalytic reaction of human UDP-glucose 6-dehydrogenase involves covalent thiohemiacetal and thioester enzyme intermediates."J. Biol. Chem. 287:2119-2129(2012) [PubMed] [Europe PMC] [Abstract]
  11. "Conformational flexibility in the allosteric regulation of human UDP-alpha-D-glucose 6-dehydrogenase."Biochemistry 50:9651-9663(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Structure and mechanism of human UDP-glucose 6-dehydrogenase."J. Biol. Chem. 286:23877-23887(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Structural basis of cooperativity in human UDP-glucose dehydrogenase."PLoS ONE 6:E25226-E25226(2011) [PubMed] [Europe PMC] [Abstract]