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Ubinuclein 1 (UBN1)

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HIRA-binding protein; Protein VT4; Ubiquitously expressed nuclear protein

Ubinuclein 1 (UBN1)
CCC G951
HGNC 12506
MGI 1891307
PubMed 22245583
RGD 1311582
UniProt Q9NPG3
A partial sequence of UBN1 had previously been identified during the cloning of the periplakin (PPL) gene. The UBN1 gene encodes a deduced 1,134-amino acid protein with a calculated molecular mass of 121,529 Da and a pI of 9.34.
Overexpression of tagged UBN1 cDNA constructs in keratinocytes revealed that the N terminus is essential for the nuclear localization, and that the central domain is responsible for the interaction with EB1 and for the phenotype of transfected keratinocytes similar to terminal differentiation. Cotransfection and overexpression of ubinuclein and EB1 revealed that the 2 proteins colocalize to the nucleus. In cells that were flat and appeared spread out on top of the basal cell layer, both proteins were also detected in a punctate pattern in the cytoplasm.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubinuclein 1 (UBN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubinuclein 1 (UBN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubinuclein 1 (UBN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubinuclein 1 (UBN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubinuclein 1 (UBN1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubinuclein 1 (UBN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubinuclein 1 (UBN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubinuclein 1 (UBN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubinuclein 1 (UBN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubinuclein 1 (UBN1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubinuclein 1 (UBN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubinuclein 1 (UBN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubinuclein 1 (UBN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubinuclein 1 (UBN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubinuclein 1 (UBN1) ELISA Kit Customized Service Offer
  1. "Ubinuclein, a novel nuclear protein interacting with cellular and viral transcription factors."J. Cell Biol. 148:1165-1176(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis."Cell 116:51-61(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization of the ubinuclein protein as a new member of the nuclear and adhesion complex components (NACos)."Biol. Cell 101:319-334(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells."Mol. Cell. Biol. 29:758-770(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]