Glutaredoxin 3 (GLRX3)
[Edit]TXNL2; PICOT; GRX3; GLRX4; GRX4; Thioredoxin-Like 2; PKC-interacting cousin of thioredoxin; PKC-theta-interacting protein; Thioredoxin-like protein 2
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It has an N-terminal thioredoxin (TXN) homology domain followed by tandem repeats of an 84-amino acid PICOT domain. Human PICOT shares 99% amino acid identity with the rat and mouse orthologs. The PICOT domain is highly conserved, and tandem PICOT domains are present in mouse and rat Picot. However, only a single PICOT domain is present in nematodes, yeast, bacteria, viruses, and plants. Northern blot analysis detected a 1.5-kb PICOT transcript in Jurkat cells. RT-PCR detected abundant PICOT expression in heart, spleen, and testis, with lower expression in other tissues. Western blot analysis detected PICOT at an apparent molecular mass of 38 kD. Fractionation of Jurkat cells revealed PICOT in the cytosolic compartment, with very low amounts in the membrane fraction.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPG979Hu01 | Recombinant Glutaredoxin 3 (GLRX3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPG979Hu02 | Recombinant Glutaredoxin 3 (GLRX3) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAG979Hu01 | Polyclonal Antibody to Glutaredoxin 3 (GLRX3) | WB; IHC; ICC; IP. |
| PAG979Hu02 | Polyclonal Antibody to Glutaredoxin 3 (GLRX3) | WB; IHC; ICC; IP. | |
| LAG979Hu71 | Biotin-Linked Polyclonal Antibody to Glutaredoxin 3 (GLRX3) | WB; IHC; ICC. | |
| LAG979Hu81 | FITC-Linked Polyclonal Antibody to Glutaredoxin 3 (GLRX3) | WB; IHC; ICC; IF. | |
| MAG979Hu21 | Monoclonal Antibody to Glutaredoxin 3 (GLRX3) | WB; IHC; ICC; IP. | |
| Assay Kits | SEG979Hu | ELISA Kit for Glutaredoxin 3 (GLRX3) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPG979Mu01 | Recombinant Glutaredoxin 3 (GLRX3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAG979Mu01 | Polyclonal Antibody to Glutaredoxin 3 (GLRX3) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Glutaredoxin 3 (GLRX3) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Glutaredoxin 3 (GLRX3) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Glutaredoxin 3 (GLRX3) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Glutaredoxin 3 (GLRX3) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Glutaredoxin 3 (GLRX3) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Glutaredoxin 3 (GLRX3) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Glutaredoxin 3 (GLRX3) | ELISA Kit Customized Service Offer |
- "Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappaB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain."J. Biol. Chem. 275:1902-1909(2000) [PubMed] [Europe PMC] [Abstract]
- "Characterization of 16 novel human genes showing high similarity to yeast sequences."Yeast 18:69-80(2001) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]