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Thioredoxin Like Protein 4 (TXNL4)

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TXNL4A; DIB1; DIM1; HsT161; U5-15kD; DIM1 protein homolog; Spliceosomal U5 snRNP-specific 15 kDa protein; Thioredoxin-like U5 snRNP protein U5-15kD

Thioredoxin Like Protein 4 (TXNL4)
CCC G984
HGNC 30551
MGI 1351613
PubMed 23519793
RGD 1308641
UniProt P83876
Wiki TXNL4A
By SDS-PAGE of human 20S U5 snRNP, followed by EST database analysis, and PCR of a HeLa cell cDNA library, Reuter et al. (1999) cloned TXNL4A, which they called U5-15KD. The deduced protein contained 142 amino acids and contains a thioredoxin-like domain. TXNL4A shares 66% sequence identity with the S. cerevisiae homolog Dib1.
Jin et al. (2006) expressed tagged DIM1 in E. coli and performed enzyme cleavage assays on the purified proteins. They found that DIM1 has peptidase activity and undergoes autocleavage. Protease inhibitors EDTA, chymostatin, and 6-aminohexanoic acid inhibited DIM1 cleavage, and the cleaved dominant-negative form of DIM1 retained the autocleavage activity of the full-length protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thioredoxin Like Protein 4 (TXNL4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thioredoxin Like Protein 4 (TXNL4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thioredoxin Like Protein 4 (TXNL4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Thioredoxin Like Protein 4 (TXNL4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thioredoxin Like Protein 4 (TXNL4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thioredoxin Like Protein 4 (TXNL4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thioredoxin Like Protein 4 (TXNL4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thioredoxin Like Protein 4 (TXNL4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Thioredoxin Like Protein 4 (TXNL4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thioredoxin Like Protein 4 (TXNL4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thioredoxin Like Protein 4 (TXNL4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thioredoxin Like Protein 4 (TXNL4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thioredoxin Like Protein 4 (TXNL4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Thioredoxin Like Protein 4 (TXNL4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thioredoxin Like Protein 4 (TXNL4) ELISA Kit Customized Service Offer
  1. "Identification, characterization and crystal structure analysis of the human spliceosomal U5 snRNP-specific 15kD protein."J. Mol. Biol. 294:515-525(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Evidence that Dim1 associates with proteins involved in pre-mRNA splicing, and delineation of residues essential for Dim1 interactions with hnRNP F and Npw38/PQBP-1."Gene 257:33-43(2000) [PubMed] [Europe PMC] [Abstract]
  5. "The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP."RNA 12:1418-1430(2006) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways."Mol. Cancer Res. 8:1388-1398(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Compound heterozygosity of low-frequency promoter deletions and rare loss-of-function mutations in TXNL4A causes Burn-McKeown syndrome." Am. J. Hum. Genet. 95:698-707(2014) [PubMed] [Europe PMC] [Abstract]
  11. "The evolutionarily conserved Dim1 protein defines a novel branch of the thioredoxin fold superfamily."Physiol. Genomics 1:109-118(1999) [PubMed] [Europe PMC] [Abstract]
  12. "Structure, stability, and function of hDim1 investigated by NMR, circular dichroism, and mutational analysis."Biochemistry 42:9609-9618(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Structural basis for the bifunctionality of the U5 snRNP 52K protein (CD2BP2)."J. Mol. Biol. 369:902-908(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Mutations in the PQBP1 gene prevent its interaction with the spliceosomal protein U5-15 kD."Nat. Commun. 5:3822-3822(2014) [PubMed] [Europe PMC] [Abstract]