≡

Thioredoxin Related Transmembrane Protein 1 (TMX1)

[Edit]

TXNDC1; TMX; TXNDC; PDIA11; Thioredoxin Domain Containing 1; Protein Disulfide Isomerase Family A Member 11; Transmembrane Trx-related protein

Thioredoxin Related Transmembrane Protein 1 (TMX1)
CCC G985
HGNC 15487
MGI 1919986
PubMed 11152479
RGD 1308455
UniProt Q9H3N1
Wiki TXNDC1
TXNDC1 is a thioredoxin (TXN)-related protein with disulfide reductase activity. The deduced 280-amino acid protein has a predicted molecular mass of 31.8 kD and contains an N-terminal signal sequence, a TRX-like domain with an active site sequence CPAC, and a transmembrane domain.
Northern blot analysis detected a 2.5-kb transcript in all tissues examined, with highest expression in kidney, liver, placenta, and lung. Confocal microscopy of intact HEK293 cells expressing TXNDC1 and Western analysis of subcellular fractions localized TXNDC1 primarily in the microsomal fraction in an endoplasmic reticulum (ER)-like staining pattern characterized by a diffuse network-like labeling of the cytoplasm and nuclear rim.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thioredoxin Related Transmembrane Protein 1 (TMX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thioredoxin Related Transmembrane Protein 1 (TMX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thioredoxin Related Transmembrane Protein 1 (TMX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Thioredoxin Related Transmembrane Protein 1 (TMX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thioredoxin Related Transmembrane Protein 1 (TMX1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thioredoxin Related Transmembrane Protein 1 (TMX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thioredoxin Related Transmembrane Protein 1 (TMX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thioredoxin Related Transmembrane Protein 1 (TMX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Thioredoxin Related Transmembrane Protein 1 (TMX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thioredoxin Related Transmembrane Protein 1 (TMX1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thioredoxin Related Transmembrane Protein 1 (TMX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thioredoxin Related Transmembrane Protein 1 (TMX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thioredoxin Related Transmembrane Protein 1 (TMX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Thioredoxin Related Transmembrane Protein 1 (TMX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thioredoxin Related Transmembrane Protein 1 (TMX1) ELISA Kit Customized Service Offer
  1. "Identification of a novel thioredoxin-related transmembrane protein."J. Biol. Chem. 276:10032-10038(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  19. "The solution structure of the thioredoxin-like domain of human thioredoxin-related transmembrane protein."Submitted (NOV-2005) to the PDB data bank