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Thioredoxin Domain Containing Protein 9 (TXNDC9)

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APACD; ATP-binding protein associated with cell differentiation

Thioredoxin Domain Containing Protein 9 (TXNDC9)
CCC G987
HGNC 24110
MGI 2138153
PubMed 12477932
RGD 708355
UniProt O14530
Wiki TXNDC9
PHLP3, encodes a 226-amino acid protein with a helical N terminus, a central thioredoxin (TXN) domain, and an acidic C terminus.
Mutation analysis revealed that both the N- and C-terminal domains of PHLP3 were required for the interaction. PHLP3 formed a ternary complex with CCT and either denatured actin or tubulin and inhibited their folding. PHLP3 did not compete with the denatured substrates and had no effect on the basal ATPase activity of CCT, but it slowed the ATPase activity of CCT in the presence of substrates. In vivo, the yeast PHLP3 homolog appeared to coordinate the proper biogenesis of actin and tubulin with prefoldin, a chaperone that facilitates CCT-mediated actin and tubulin folding.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thioredoxin Domain Containing Protein 9 (TXNDC9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thioredoxin Domain Containing Protein 9 (TXNDC9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thioredoxin Domain Containing Protein 9 (TXNDC9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Thioredoxin Domain Containing Protein 9 (TXNDC9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thioredoxin Domain Containing Protein 9 (TXNDC9) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thioredoxin Domain Containing Protein 9 (TXNDC9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thioredoxin Domain Containing Protein 9 (TXNDC9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thioredoxin Domain Containing Protein 9 (TXNDC9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Thioredoxin Domain Containing Protein 9 (TXNDC9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thioredoxin Domain Containing Protein 9 (TXNDC9) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thioredoxin Domain Containing Protein 9 (TXNDC9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thioredoxin Domain Containing Protein 9 (TXNDC9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thioredoxin Domain Containing Protein 9 (TXNDC9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Thioredoxin Domain Containing Protein 9 (TXNDC9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thioredoxin Domain Containing Protein 9 (TXNDC9) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "PhLP3 modulates CCT-mediated actin and tubulin folding via ternary complexes with substrates."J. Biol. Chem. 281:7012-7021(2006) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]