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Transformation/Transcription Domain Associated Protein (TRRAP)

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STAF40; TR-AP; Tra1; 350/400 kDa PCAF-associated factor

Transformation/Transcription Domain Associated Protein (TRRAP)
CCC G996
HGNC 12347
MGI 2153272
PubMed 23362228
RGD 1305446
UniProt Q9Y4A5
Wiki TRRAP
TRRAP is an adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which in turn is responsible for epigenetic transcription activation. TRRAP a central role in MYC (c-Myc) transcription activation, and also participates in cell transformation by MYC.
TRRAP is also required for the mitotic checkpoint and normal cell cycle progression. The MRN complex (composed of MRE11, RAD50 (gene), and NBS1) is involved in the detection and repair of DNA double-strand breaks (DSBs). TRRAP associates with the MRN complex and when TRRAP is removed, the complex shows reduced cDNA end-joining activity. Hence TRRAP may function as a link between DSB repair and chromatin remodeling.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG996Hu01 Recombinant Transformation/Transcription Domain Associated Protein (TRRAP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG996Hu01 Polyclonal Antibody to Transformation/Transcription Domain Associated Protein (TRRAP) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Transformation/Transcription Domain Associated Protein (TRRAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transformation/Transcription Domain Associated Protein (TRRAP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transformation/Transcription Domain Associated Protein (TRRAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transformation/Transcription Domain Associated Protein (TRRAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transformation/Transcription Domain Associated Protein (TRRAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transformation/Transcription Domain Associated Protein (TRRAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transformation/Transcription Domain Associated Protein (TRRAP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transformation/Transcription Domain Associated Protein (TRRAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transformation/Transcription Domain Associated Protein (TRRAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transformation/Transcription Domain Associated Protein (TRRAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transformation/Transcription Domain Associated Protein (TRRAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transformation/Transcription Domain Associated Protein (TRRAP) ELISA Kit Customized Service Offer
  1. "The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins."Cell 94:363-374(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily."Mol. Cell 2:869-875(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo."Mol. Cell. Biol. 21:6782-6795(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction."J. Biol. Chem. 274:18285-18289(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis."Cell 102:463-473(2000) [PubMed] [Europe PMC] [Abstract]
  8. "The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc."Mol. Cell. Biol. 20:556-562(2000) [PubMed] [Europe PMC] [Abstract]
  9. "E2F transcriptional activation requires TRRAP and GCN5 cofactors."J. Biol. Chem. 276:32627-32634(2001) [PubMed] [Europe PMC] [Abstract]
  10. "The ATM-related domain of TRRAP is required for histone acetyltransferase recruitment and Myc-dependent oncogenesis."Genes Dev. 15:1619-1624(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Transcriptional regulation of the mdm2 oncogene by p53 requires TRRAP acetyltransferase complexes."Mol. Cell. Biol. 22:5650-5661(2002) [PubMed] [Europe PMC] [Abstract]
  12. "BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation."Mol. Cell. Biol. 22:1307-1316(2002) [PubMed] [Europe PMC] [Abstract]
  13. "The adenovirus E1A oncoprotein recruits the cellular TRRAP/GCN5 histone acetyltransferase complex."Oncogene 22:2836-2841(2003) [PubMed] [Europe PMC] [Abstract]
  14. "c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation."J. Biol. Chem. 278:20405-20412(2003) [PubMed] [Europe PMC] [Abstract]
  15. "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans."Mol. Cell. Biol. 24:1884-1896(2004) [PubMed] [Europe PMC] [Abstract]
  16. "A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing."Mol. Cell 29:92-101(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Transcriptional activation of histone genes requires NPAT-dependent recruitment of TRRAP-Tip60 complex to histone promoters during the G1/S phase transition."Mol. Cell. Biol. 28:435-447(2008) [PubMed] [Europe PMC] [Abstract]
  19. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly."J. Biol. Chem. 285:20109-20116(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  24. "Exome sequencing identifies GRIN2A as frequently mutated in melanoma."Nat. Genet. 43:442-446(2011) [PubMed] [Europe PMC] [Abstract]
  25. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  26. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  27. "ANP32E is a histone chaperone that removes H2A.Z from chromatin."Nature 505:648-653(2014) [PubMed] [Europe PMC] [Abstract]
  28. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]