≡

Thyroid Hormone Receptor Interactor 4 (TRIP4)

[Edit]

ASC-1; Activating signal cointegrator 1

Thyroid Hormone Receptor Interactor 4 (TRIP4)
CCC H003
HGNC 12310
MGI 1928469
PubMed 10454579
UniProt Q15650
Wiki TRIP4
The thyroid hormone receptors (TRs) are hormone-dependent transcription factors that regulate expression of a variety of specific target genes. They must specifically interact with a number of proteins as they progress from their initial translation and nuclear translocation to heterodimerization with retinoid X receptors (RXRs), functional interactions with other transcription factors and the basic transcriptional apparatus, and eventually, degradation.
TRIP4 interacted with rat Thrb only in the presence of thyroid hormone. It also showed a ligand-dependent interaction with RXR-alpha, but did not interact with the glucocorticoid receptor under any condition. TRIP4 contains a putative zinc finger motif with an arrangement of cysteines nearly identical to that of the zinc-binding sequence in the adenovirus E1A transactivator.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thyroid Hormone Receptor Interactor 4 (TRIP4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thyroid Hormone Receptor Interactor 4 (TRIP4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thyroid Hormone Receptor Interactor 4 (TRIP4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Thyroid Hormone Receptor Interactor 4 (TRIP4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thyroid Hormone Receptor Interactor 4 (TRIP4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thyroid Hormone Receptor Interactor 4 (TRIP4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thyroid Hormone Receptor Interactor 4 (TRIP4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thyroid Hormone Receptor Interactor 4 (TRIP4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Thyroid Hormone Receptor Interactor 4 (TRIP4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thyroid Hormone Receptor Interactor 4 (TRIP4) ELISA Kit Customized Service Offer
  1. "Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation."Mol. Cell. Biol. 19:6323-6332(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor."Mol. Endocrinol. 9:243-254(1995) [PubMed] [Europe PMC] [Abstract]
  5. "Activating signal cointegrator 1 is highly expressed in murine testicular Leydig cells and enhances the ligand-dependent transactivation of androgen receptor."Biol. Reprod. 67:1580-1587(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Novel transcription coactivator complex containing activating signal cointegrator 1."Mol. Cell. Biol. 22:5203-5211(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome."J. Proteome Res. 9:6298-6316(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Modification of ASC1 by UFM1 is crucial for ERalpha transactivation and breast cancer development."Mol. Cell 56:261-274(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Solution structure of the TRIP_4C domain of target of activating signal cointegrator 1."Submitted (DEC-2006) to the PDB data bank