≡

Tumor Protein p53 Binding Protein 1 (TP53BP1)

[Edit]

53BP1; p53BP1; p202

Tumor Protein p53 Binding Protein 1 (TP53BP1)
CCC H009
HGNC 11999
MGI 1351320
PubMed 21635553
RGD 1308039
UniProt Q12888
Wiki TP53BP1
TP53BP1 has a predicted molecular mass of 217 kD and shows homology in its C-terminal 247 amino acids to the C terminus of the tumor suppressor protein BRCA1. TP53BP1 was present in both the cytoplasm and nucleus in some cells and only in the nucleus in others. Furthermore, there were 2 nuclear staining patterns, one homogeneous staining and the other dot staining.TP53BP1 was required for p53 accumulation, G2/M checkpoint arrest, and the intra-S-phase checkpoint in response to ionizing radiation. TP53BP1 played a partially redundant role in phosphorylation of the downstream checkpoint effector proteins BRCA1 and CHK2 but was required for the formation of BRCA1 foci in a hierarchical branched pathway for the recruitment of repair and signaling proteins to sites of DNA damage.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH009Hu01 Recombinant Tumor Protein p53 Binding Protein 1 (TP53BP1) Positive Control; Immunogen; SDS-PAGE; WB.
MPH009Hu01 Phosphorylated Tumor Protein p53 Binding Protein 1 (TP53BP1) n/a
Antibodies MAH009Hu21 Monoclonal Antibody to Tumor Protein p53 Binding Protein 1 (TP53BP1) WB; IHC; ICC; IP.
PAH009Hu01 Polyclonal Antibody to Tumor Protein p53 Binding Protein 1 (TP53BP1) WB; IHC; ICC; IP.
AAH009Hu01 Anti-Phosphorylated Tumor Protein p53 Binding Protein 1 (TP53BP1) Polyclonal Antibody WB.
AAH009Hu02 Anti-Phosphorylated Tumor Protein p53 Binding Protein 1 (TP53BP1) Monoclonal Antibody WB.
Assay Kits SEH009Hu ELISA Kit for Tumor Protein p53 Binding Protein 1 (TP53BP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tumor Protein p53 Binding Protein 1 (TP53BP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tumor Protein p53 Binding Protein 1 (TP53BP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tumor Protein p53 Binding Protein 1 (TP53BP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tumor Protein p53 Binding Protein 1 (TP53BP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tumor Protein p53 Binding Protein 1 (TP53BP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tumor Protein p53 Binding Protein 1 (TP53BP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tumor Protein p53 Binding Protein 1 (TP53BP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tumor Protein p53 Binding Protein 1 (TP53BP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tumor Protein p53 Binding Protein 1 (TP53BP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tumor Protein p53 Binding Protein 1 (TP53BP1) ELISA Kit Customized Service Offer
  1. "Stimulation of p53-mediated transcriptional activation by the p53-binding proteins, 53BP1 and 53BP2."J. Biol. Chem. 273:26061-26068(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Two cellular proteins that bind to wild-type but not mutant p53."Proc. Natl. Acad. Sci. U.S.A. 91:6098-6102(1994) [PubMed] [Europe PMC] [Abstract]
  6. "Negative cell cycle regulation and DNA-damage inducible phosphorylation of the BRCT protein 53BP1."J. Biol. Chem. 276:2708-2718(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways."J. Cell Biol. 153:613-620(2001) [PubMed] [Europe PMC] [Abstract]
  8. "53BP1, a mediator of the DNA damage checkpoint."Science 298:1435-1438(2002) [PubMed] [Europe PMC] [Abstract]
  9. "MDC1 is a mediator of the mammalian DNA damage checkpoint."Nature 421:961-966(2003) [PubMed] [Europe PMC] [Abstract]
  10. "p53-Binding protein 1 is fused to the platelet-derived growth factor receptor beta in a patient with a t(5;15)(q33;q22) and an imatinib-responsive eosinophilic myeloproliferative disorder."Cancer Res. 64:7216-7219(2004) [PubMed] [Europe PMC] [Abstract]
  11. "A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci."Mol. Cell 16:715-724(2004) [PubMed] [Europe PMC] [Abstract]
  12. "The GAR motif of 53BP1 is arginine methylated by PRMT1 and is necessary for 53BP1 DNA binding activity."Cell Cycle 4:1834-1841(2005) [PubMed] [Europe PMC] [Abstract]
  13. "53BP1 oligomerization is independent of its methylation by PRMT1."Cell Cycle 4:1854-1861(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  15. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Characterisation of the sites of DNA damage-induced 53BP1 phosphorylation catalysed by ATM and ATR."DNA Repair 6:1536-1544(2007) [PubMed] [Europe PMC] [Abstract]
  17. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  18. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  19. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Protein phosphatase 5 regulates the function of 53BP1 after neocarzinostatin-induced DNA damage."J. Biol. Chem. 284:9845-9853(2009) [PubMed] [Europe PMC] [Abstract]
  22. "p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage."J. Cell. Physiol. 221:594-602(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Regulation of chromatin architecture by the PWWP domain-containing DNA damage-responsive factor EXPAND1/MUM1."Mol. Cell 37:854-864(2010) [PubMed] [Europe PMC] [Abstract]
  25. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  26. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  27. "Protein phosphatase 5 is necessary for ATR-mediated DNA repair."Biochem. Biophys. Res. Commun. 404:476-481(2011) [PubMed] [Europe PMC] [Abstract]
  28. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  29. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  30. "Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor."EMBO J. 21:3863-3872(2002) [PubMed] [Europe PMC] [Abstract]
  31. "Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure."Genes Dev. 16:583-593(2002) [PubMed] [Europe PMC] [Abstract]
  32. "Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks."Nature 432:406-411(2004) [PubMed] [Europe PMC] [Abstract]
  33. "Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair."Cell 127:1361-1373(2006) [PubMed] [Europe PMC] [Abstract]