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Toll Like Receptor Adaptor Molecule 1 (TICAM1)

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TRIF; PRVTIRB; Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta; Proline-rich, vinculin and TIR domain-containing protein B

Toll Like Receptor Adaptor Molecule 1 (TICAM1)
CCC H022
HGNC 18348
MGI 2147032
PubMed 22205631
UniProt Q8IUC6
Wiki Trif
TRIF is primarily active in the spleen and is often regulated when MyD88 is deficient in the liver, indicating organ-specific regulation of signaling pathways. Curiously, there is a lack of redundancy within the TLR4 signaling pathway that leads to microbial evasion of immune response in the host after mutations occur within intermediates of the pathway. Three TRAF-binding motifs present in the amino terminal region of TRIF are necessary for association with TRAF6. Destruction of these motifs reduced the activation of NF-κβ, a transcription factor that is also activated by the carboxy-terminal domain of TRIF in the upregulation of cytokines and co-stimulatory immune molecules. This domain recruits receptor-interacting protein (RIP1) and RIP3 through the RIP homotypic interaction motif.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH022Hu01 Recombinant Toll Like Receptor Adaptor Molecule 1 (TICAM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAH022Hu21 Monoclonal Antibody to Toll Like Receptor Adaptor Molecule 1 (TICAM1) WB; IHC; ICC; IP.
PAH022Hu01 Polyclonal Antibody to Toll Like Receptor Adaptor Molecule 1 (TICAM1) WB; IHC; ICC; IP.
Assay Kits SEH022Hu ELISA Kit for Toll Like Receptor Adaptor Molecule 1 (TICAM1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH022Mu01 Recombinant Toll Like Receptor Adaptor Molecule 1 (TICAM1) Positive Control; Immunogen; SDS-PAGE; WB.
RPH022Mu02 Recombinant Toll Like Receptor Adaptor Molecule 1 (TICAM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH022Mu01 Polyclonal Antibody to Toll Like Receptor Adaptor Molecule 1 (TICAM1) WB; IHC; ICC; IP.
PAH022Mu02 Polyclonal Antibody to Toll Like Receptor Adaptor Molecule 1 (TICAM1) WB; IHC; ICC; IP.
Assay Kits SEH022Mu ELISA Kit for Toll Like Receptor Adaptor Molecule 1 (TICAM1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling."J. Immunol. 169:6668-6672(2002) [PubMed] [Europe PMC] [Abstract]
  2. "TICAM-1, an adapter molecule that participates in Toll-like receptor 3 mediated interferon-beta induction."Nat. Immunol. 4:161-167(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Natural selection in the TLR-related genes in the course of primate evolution."Immunogenetics 60:727-735(2008) [PubMed] [Europe PMC] [Abstract]
  4. "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling."J. Biol. Chem. 278:24526-24532(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling."J. Immunol. 171:4304-4310(2003) [PubMed] [Europe PMC] [Abstract]
  8. "PIASy represses TRIF-induced ISRE and NF-kappaB activation but not apoptosis."FEBS Lett. 570:97-101(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways."J. Biol. Chem. 279:15652-15661(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta."Proc. Natl. Acad. Sci. U.S.A. 101:3533-3538(2004) [PubMed] [Europe PMC] [Abstract]
  11. "NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation."J. Immunol. 174:27-30(2005) [PubMed] [Europe PMC] [Abstract]
  12. "The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling."Nat. Immunol. 7:1074-1081(2006) [PubMed] [Europe PMC] [Abstract]
  13. "The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling."Nat. Rev. Immunol. 7:353-364(2007) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  15. "TRIM38 negatively regulates TLR3-mediated IFN-beta signaling by targeting TRIF for degradation."PLoS ONE 7:E46825-E46825(2012) [PubMed] [Europe PMC] [Abstract]
  16. "The TLR signalling adaptor TRIF/TICAM-1 has an N-terminal helical domain with structural similarity to IFIT proteins."Acta Crystallogr. D 69:2420-2430(2013) [PubMed] [Europe PMC] [Abstract]
  17. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  18. "Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency." J. Clin. Invest. 121:4889-4902(2011) [PubMed] [Europe PMC] [Abstract]