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Transcription Factor EC (TFEC)

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TCFEC; TFECL; BHLHE34; Transcription factor EC-like; Class E basic helix-loop-helix protein 34

Transcription Factor EC (TFEC)
CCC H041
HGNC 11754
MGI 1333760
PubMed 15908341
RGD 3846
UniProt O14948
Wiki TFEC
Zhao et al. (1993) identified in rat a transcriptional repressor with a basic helix-loop-helix and leucine zipper (bHLH/LZ) structure closely related to that in human microphthalmia-associated transcription factor (MITF) and TFE3. By screening a THP-1 human monocytic leukemia cell line with an MITF cDNA fragment coding for the bHLH/LZ region, Yasumoto and Shibahara (1997) cloned a TFEC cDNA, which they symbolized TFECL. The TFEC cDNA encodes a deduced 347-amino acid protein with a bHLH/LZ region that binds a CANNTG motif, known as an E box, and shares high homology to rat TFEC, mouse Tfe3, and MITF. Human TFEC contains an acidic domain that corresponds to a transcriptional activation domain of TFE3, but its equivalent region is deleted in rat TFEC.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription Factor EC (TFEC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription Factor EC (TFEC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription Factor EC (TFEC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription Factor EC (TFEC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription Factor EC (TFEC) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription Factor EC (TFEC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription Factor EC (TFEC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription Factor EC (TFEC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription Factor EC (TFEC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription Factor EC (TFEC) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription Factor EC (TFEC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription Factor EC (TFEC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription Factor EC (TFEC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription Factor EC (TFEC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription Factor EC (TFEC) ELISA Kit Customized Service Offer
  1. "Molecular cloning of cDNA encoding a human TFEC isoform, a newly identified transcriptional regulator."Biochim. Biophys. Acta 1353:23-31(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Regulation of the MiTF/TFE bHLH-LZ transcription factors through restricted spatial expression and alternative splicing of functional domains."Nucleic Acids Res. 32:2315-2322(2004) [PubMed] [Europe PMC] [Abstract]
  7. "TFEC can function as a transcriptional activator of the nonmuscle myosin II heavy chain-A gene in transfected cells."Biochemistry 40:8887-8897(2001) [PubMed] [Europe PMC] [Abstract]
  8. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]