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Transcription Factor AP2 Beta (TFAP2b)

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AP2-B; Activating Enhancer Binding Protein 2 Beta

Transcription Factor AP2 Beta (TFAP2b)
CCC H047
HGNC 11743
MGI 104672
PubMed 10802654
RGD 1306321
UniProt Q92481
Wiki TFAP2B
AP-2 beta is a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor.
The predicted protein differs from AP-2-alpha and -gamma in the N-terminal activation domain, but is 75 to 85% conserved within the DNA-binding and dimerization domains. All 3 gene products (AP-2-alpha, -beta, and -gamma) bind the GCCNNNGGC motif.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription Factor AP2 Beta (TFAP2b) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription Factor AP2 Beta (TFAP2b) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription Factor AP2 Beta (TFAP2b) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription Factor AP2 Beta (TFAP2b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription Factor AP2 Beta (TFAP2b) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription Factor AP2 Beta (TFAP2b) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription Factor AP2 Beta (TFAP2b) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription Factor AP2 Beta (TFAP2b) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription Factor AP2 Beta (TFAP2b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription Factor AP2 Beta (TFAP2b) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription Factor AP2 Beta (TFAP2b) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription Factor AP2 Beta (TFAP2b) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription Factor AP2 Beta (TFAP2b) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription Factor AP2 Beta (TFAP2b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription Factor AP2 Beta (TFAP2b) ELISA Kit Customized Service Offer
  1. "Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2beta."Genes Dev. 11:1938-1948(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Chromosomal mapping of the human and mouse homologues of two new members of the AP-2 family of transcription factors."Genomics 35:262-264(1996) [PubMed] [Europe PMC] [Abstract]
  5. "Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator."Nat. Genet. 29:469-474(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2."J. Biol. Chem. 277:8559-8565(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo."J. Biol. Chem. 277:30798-30804(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2."J. Biol. Chem. 278:16021-16029(2003) [PubMed] [Europe PMC] [Abstract]
  9. "The interaction of KCTD1 with transcription factor AP-2alpha inhibits its transactivation."J. Cell. Biochem. 106:285-295(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Mutations in TFAP2B cause Char syndrome, a familial form of patent ductus arteriosus."Nat. Genet. 25:42-46(2000) [PubMed] [Europe PMC] [Abstract]
  11. "Novel TFAP2B mutations that cause Char syndrome provide a genotype-phenotype correlation."Am. J. Hum. Genet. 69:695-703(2001) [PubMed] [Europe PMC] [Abstract]