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Transcription Factor AP2 Alpha (TFAP2a)

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AP-2; AP-2alpha; AP2TF; TFAP2; Activating Enhancer-Binding Protein 2 Alpha; Activator protein 2

Transcription Factor AP2 Alpha (TFAP2a)
CCC H048
HGNC 11742
MGI 104671
PubMed 18423521
RGD 1310267
UniProt P05549
Wiki TFAP2A
The AP-2 alpha protein acts as a sequence specific DNA-binding transcription factor recognizing and binding to the specific DNA sequence and recruiting transcription machinery. Its binding site is a GC-rich sequence that is present in the cis-regulatory regions of several viral and cellular genes. AP2-alpha is a 52-kD retinoic acid-inducible and developmentally regulated activator of transcription that binds to a consensus DNA-binding sequence CCCCAGGC in the SV40 and metallothionein promoters.
AP-2 alpha is expressed in neural crest cell lineages with the highest levels of expression corresponding to early neural crest cells suggesting that AP-2 alpha plays a role in their differentiation and development.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription Factor AP2 Alpha (TFAP2a) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription Factor AP2 Alpha (TFAP2a) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription Factor AP2 Alpha (TFAP2a) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription Factor AP2 Alpha (TFAP2a) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription Factor AP2 Alpha (TFAP2a) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription Factor AP2 Alpha (TFAP2a) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription Factor AP2 Alpha (TFAP2a) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription Factor AP2 Alpha (TFAP2a) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription Factor AP2 Alpha (TFAP2a) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription Factor AP2 Alpha (TFAP2a) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription Factor AP2 Alpha (TFAP2a) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription Factor AP2 Alpha (TFAP2a) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription Factor AP2 Alpha (TFAP2a) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription Factor AP2 Alpha (TFAP2a) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription Factor AP2 Alpha (TFAP2a) ELISA Kit Customized Service Offer
  1. "Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements."Genes Dev. 2:1557-1569(1988) [PubMed] [Europe PMC] [Abstract]
  2. "An alternatively spliced mRNA from the AP-2 gene encodes a negative regulator of transcriptional activation by AP-2."Mol. Cell. Biol. 13:4174-4185(1993) [PubMed] [Europe PMC] [Abstract]
  3. "The genomic structure of the human AP-2 transcription factor."Nucleic Acids Res. 22:1413-1420(1994) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization of a dimerization motif in AP-2 and its function in heterologous DNA-binding proteins."Science 251:1067-1071(1991) [PubMed] [Europe PMC] [Abstract]
  7. "Analysis of the DNA-binding and activation properties of the human transcription factor AP-2."Genes Dev. 5:670-682(1991) [PubMed] [Europe PMC] [Abstract]
  8. "Transcription factor AP-2 activity is modulated by protein kinase A-mediated phosphorylation."FEBS Lett. 444:27-31(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator."Nat. Genet. 29:469-474(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2."J. Biol. Chem. 277:8559-8565(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo."J. Biol. Chem. 277:30798-30804(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2."J. Biol. Chem. 278:16021-16029(2003) [PubMed] [Europe PMC] [Abstract]
  13. "RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis."J. Biol. Chem. 278:30597-30604(2003) [PubMed] [Europe PMC] [Abstract]
  14. "Physical and functional interactions between the Wwox tumor suppressor protein and the AP-2gamma transcription factor."Cancer Res. 64:8256-8261(2004) [PubMed] [Europe PMC] [Abstract]
  15. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  16. "The interaction of KCTD1 with transcription factor AP-2alpha inhibits its transactivation."J. Cell. Biochem. 106:285-295(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Inhibition of neural crest formation by Kctd15 involves regulation of transcription factor AP-2."Proc. Natl. Acad. Sci. U.S.A. 110:2870-2875(2013) [PubMed] [Europe PMC] [Abstract]
  18. "TFAP2A mutations result in branchio-oculo-facial syndrome."Am. J. Hum. Genet. 82:1171-1177(2008) [PubMed] [Europe PMC] [Abstract]