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Transcription Factor A, Mitochondrial (TFAM)

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MtTF1; TCF6; TCF6L2; mtTFA; Mitochondrial transcription factor 1; Transcription factor 6-like 2

Transcription Factor A, Mitochondrial (TFAM)
CCC H050
HGNC 11741
MGI 107810
PubMed 23201127
RGD 620682
UniProt Q00059
Wiki TFAM
TFAM encodes a mitochondrial transcription factor that is a key activator of mitochondrial transcription as well as a participant in mitochondrial genome replication. Studies in mice have demonstrated that this gene product is required to regulate the mitochondrial genome copy number and is essential for embryonic development. A mouse model for Kearns-Sayre syndrome was produced when expression of this gene was eliminated by targeted disruption in heart and muscle cells.The mature TCF6 gene product, mitochondrial transcription factor A (TFAM; also known as mtTF1 or mtTFA), is a 162-amino acid protein that activates transcription of each mitochondrial DNA (mtDNA) strand by binding to an element of approximately 30 nucleotides present in both the light-strand and the heavy-strand promoters.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH050Hu01 Recombinant Transcription Factor A, Mitochondrial (TFAM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH050Hu01 Polyclonal Antibody to Transcription Factor A, Mitochondrial (TFAM) WB; IHC; ICC; IP.
MAH050Hu21 Monoclonal Antibody to Transcription Factor A, Mitochondrial (TFAM) WB; IHC; ICC; IP.
Assay Kits SEH050Hu ELISA Kit for Transcription Factor A, Mitochondrial (TFAM) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH050Mu01 Recombinant Transcription Factor A, Mitochondrial (TFAM) Positive Control; Immunogen; SDS-PAGE; WB.
RPH050Mu02 Recombinant Transcription Factor A, Mitochondrial (TFAM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH050Mu01 Polyclonal Antibody to Transcription Factor A, Mitochondrial (TFAM) WB; IHC; ICC; IP.
LAH050Mu81 FITC-Linked Polyclonal Antibody to Transcription Factor A, Mitochondrial (TFAM) WB; IHC; ICC; IF.
LAH050Mu71 Biotin-Linked Polyclonal Antibody to Transcription Factor A, Mitochondrial (TFAM) WB; IHC; ICC.
PAH050Mu02 Polyclonal Antibody to Transcription Factor A, Mitochondrial (TFAM) WB; IHC; ICC; IP.
Assay Kits SEH050Mu ELISA Kit for Transcription Factor A, Mitochondrial (TFAM) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH050Ra01 Recombinant Transcription Factor A, Mitochondrial (TFAM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH050Ra01 Polyclonal Antibody to Transcription Factor A, Mitochondrial (TFAM) WB; IHC; ICC; IP.
LAH050Ra81 FITC-Linked Polyclonal Antibody to Transcription Factor A, Mitochondrial (TFAM) WB; IHC; ICC; IF.
LAH050Ra71 Biotin-Linked Polyclonal Antibody to Transcription Factor A, Mitochondrial (TFAM) WB; IHC; ICC.
Assay Kits SEH050Ra ELISA Kit for Transcription Factor A, Mitochondrial (TFAM) Enzyme-linked immunosorbent assay for Antigen Detection.
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  8. "Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity."Mol. Cell. Biol. 23:5816-5824(2003) [PubMed] [Europe PMC] [Abstract]
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  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Human mitochondrial transcription revisited: only TFAM and TFB2M are required for transcription of the mitochondrial genes in vitro."J. Biol. Chem. 285:18129-18133(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
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  14. "Maintenance of mitochondrial genome distribution by mitochondrial AAA+ protein ClpX."Exp. Cell Res. 318:2335-2343(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Phosphorylation of human TFAM in mitochondria impairs DNA binding and promotes degradation by the AAA+ Lon protease."Mol. Cell 49:121-132(2013) [PubMed] [Europe PMC] [Abstract]
  16. "Structural analysis and DNA binding of the HMG domains of the human mitochondrial transcription factor A."Nucleic Acids Res. 37:3153-3164(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Human mitochondrial transcription factor A induces a U-turn structure in the light strand promoter."Nat. Struct. Mol. Biol. 18:1281-1289(2011) [PubMed] [Europe PMC] [Abstract]
  18. "The mitochondrial transcription and packaging factor Tfam imposes a U-turn on mitochondrial DNA."Nat. Struct. Mol. Biol. 18:1290-1296(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Mitochondrial transcription factors TFA, TFB1 and TFB2: a search for DNA variants/haplotypes and the risk of cardiac hypertrophy."Dis. Markers 25:131-139(2008) [PubMed] [Europe PMC] [Abstract]