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Zinc Finger Homeobox Protein 1A (ZFHX1A)

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ZEB1; AREB6; BZP; NIL-2A; ZEB; ZFHEP; TCF8; NIL-2-A zinc finger protein; Zinc Finger E-Box Binding Homeobox 1; Represses Interleukin 2 Expression; Transcription Factor 8

Zinc Finger Homeobox Protein 1A (ZFHX1A)
CCC H055
HGNC 11642
MGI 1344313
PubMed 16510593
RGD 3831
UniProt P37275
TCF8 encodes a human zinc finger transcription factor that represses T-lymphocyte-specific IL2 gene expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site.
Delta-Ef1 selectively transactivated the promoters of the SMC differentiation marker genes Acta2 and Myh11, and it physically interacted with Srf and Smad3, resulting in synergistic activation of the Acta2 promoter. Chromatin immunoprecipitation assays and knockdown experiments showed that delta-Ef1 was involved in control of SMC differentiation programs induced by Tgf-beta (TGFB1) signaling. Overexpression of delta-Ef1 inhibited neointima formation and promoted SMC differentiation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH055Hu01 Recombinant Zinc Finger Homeobox Protein 1A (ZFHX1A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH055Hu01 Polyclonal Antibody to Zinc Finger Homeobox Protein 1A (ZFHX1A) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Zinc Finger Homeobox Protein 1A (ZFHX1A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger Homeobox Protein 1A (ZFHX1A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger Homeobox Protein 1A (ZFHX1A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger Homeobox Protein 1A (ZFHX1A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger Homeobox Protein 1A (ZFHX1A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger Homeobox Protein 1A (ZFHX1A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger Homeobox Protein 1A (ZFHX1A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger Homeobox Protein 1A (ZFHX1A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger Homeobox Protein 1A (ZFHX1A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger Homeobox Protein 1A (ZFHX1A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger Homeobox Protein 1A (ZFHX1A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger Homeobox Protein 1A (ZFHX1A) ELISA Kit Customized Service Offer
  1. "Transcription factors positively and negatively regulating the Na,K-ATPase alpha 1 subunit gene."J. Biochem. 114:849-855(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of a zinc finger protein that inhibits IL-2 gene expression."Science 254:1791-1794(1991) [PubMed] [Europe PMC] [Abstract]
  6. "Mutations in TCF8 cause posterior polymorphous corneal dystrophy and ectopic expression of COL4A3 by corneal endothelial cells." Am. J. Hum. Genet. 77:694-708(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin."J. Biol. Chem. 280:35477-35489(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs."Nat. Cell Biol. 11:1487-1495(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "ZEB1 and CtBP form a repressive complex at a distal promoter element of the BCL6 locus."Biochem. J. 427:541-550(2010) [PubMed] [Europe PMC] [Abstract]
  14. "ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1."Oncogene 29:3490-3500(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Solution structure of the homeobox domain from human NIL-2-A zinc finger protein, transcription factor 8."Submitted (APR-2007) to the PDB data bank
  18. "Missense mutations in TCF8 cause late-onset Fuchs corneal dystrophy and interact with FCD4 on chromosome 9p."Am. J. Hum. Genet. 86:45-53(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Mutational spectrum of the ZEB1 gene in corneal dystrophies supports a genotype-phenotype correlation."Invest. Ophthalmol. Vis. Sci. 54:3215-3223(2013) [PubMed] [Europe PMC] [Abstract]
  20. "Functional impact of ZEB1 mutations associated with posterior polymorphous and Fuchs' endothelial corneal dystrophies."Invest. Ophthalmol. Vis. Sci. 55:6159-6166(2014) [PubMed] [Europe PMC] [Abstract]